Chemical Compound Review:
lactate 2-hydroxypropanoic acid
Synonyms:
lactasol, Polactide, Biolac, Lactovagan, Milchsaure, ...
Timothy W. Lovenberg,
M. Zamirul Hussain,
Q. Perveen Ghani,
Su Jin Yun,
Sashwati Roy,
Onishi,
Christopher D. Byrne,
Bénédicte F. Jordan,
Silvia Wagner,
Iain T. Cameron,
Frédérique Végran,
Saitoh,
Stephanie Coakley,
Gerzeli,
Rajiv Sreekumar,
Trevenzoli,
Campostrini,
Taraneh Mirzadegan,
Staffan Enoksson,
Changlu Liu,
Veronica Qvisth,
Bauer,
Eva Hagström-Toft,
Ishida,
Chantal D. Simonis,
Chandan K. Sen,
Christophe J. De Saedeleer,
Thies Schroeder,
Chester Kuei,
Cattelan,
Steven W. Sutton,
Olivier Feron,
Jan Bolinder,
Kitamoto,
Nagamori,
Curt Mazur,
Bernard Gallez,
Kelly M. Kennedy,
Thomas K. Hunt,
Zahid N. Rabbani,
Sasset,
Jonathan Shelton,
Michael J. Kelley,
Ananth Vijendren,
Malcolm C. Richardson,
Chiarelli,
Melanie C. Wergin,
Fredrik Kamme,
Stefan Beckert,
Jingxue Yu,
Mark W. Dewhirst,
Takahashi,
Julien Verrax,
Xiaorong Li,
Jiejun Wu,
Caroline Diepart,
Pagiaro,
Facchin,
Susan Ingamells,
Pierre Sonveaux,
Rummana S. Aslam,
Miriam L. Wahl,
Tokuhiro,
Jessica Zhu,
Cadrobbi,
Luckni Sellahewa,
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- Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype. Serganova, I., Rizwan, A., Ni, X., Thakur, S.B., Vider, J., Russell, J., Blasberg, R., Koutcher, J.A. Clin. Cancer Res. (2011)
- Cerebral blood flow changes during sodium-lactate-induced panic attacks. Stewart, R.S., Devous, M.D., Rush, A.J., Lane, L., Bonte, F.J. The American journal of psychiatry. (1988)
- Thin-film microbiosensors for glucose-lactate monitoring. Jobst, G., Moser, I., Varahram, M., Svasek, P., Aschauer, E., Trajanoski, Z., Wach, P., Kotanko, P., Skrabal, F., Urban, G. Anal. Chem. (1996)
- L-lactate uptake by rat liver. Effect of food deprivation and substrate availability. Felipe, A., Remesar, X., Pastor-Anglada, M. Biochem. J. (1991)
- Expansion and fixation properties of a new braided biodegradable urethral stent: an experimental study in the rabbit. Vaajanen, A., Nuutinen, J.P., Isotalo, T., Törmälä, P., Tammela, T.L., Talja, M. J. Urol. (2003)
- Use of polylactic acid implants to correct facial lipoatrophy in human immunodeficiency virus 1-positive individuals receiving combination antiretroviral therapy. Cattelan, A.M., Bauer, U., Trevenzoli, M., Sasset, L., Campostrini, S., Facchin, C., Pagiaro, E., Gerzeli, S., Cadrobbi, P., Chiarelli, A. Archives of dermatology. (2006)
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- Selective disruption of protein aggregation by cyclodextrin dimers. Leung, D.K., Yang, Z., Breslow, R. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride. Ichihara, T., Sakamoto, K., Mori, K., Akagi, M. Cancer Res. (1989)
- Allosteric effect of fructose 1,6-bisphosphate on the conformation of NAD+ as bound to L-lactate dehydrogenase from Thermus caldophilus GK24. Machida, M., Yokoyama, S., Matsuzawa, H., Miyazawa, T., Ohta, T. J. Biol. Chem. (1985)
- The role of glycine 99 in L-lactate monooxygenase from Mycobacterium smegmatis. Sun, W., Williams, C.H., Massey, V. J. Biol. Chem. (1997)
- Conversion of L-lactate oxidase to a long chain alpha-hydroxyacid oxidase by site-directed mutagenesis of alanine 95 to glycine. Yorita, K., Aki, K., Ohkuma-Soyejima, T., Kokubo, T., Misaki, H., Massey, V. J. Biol. Chem. (1996)
- Conformation of NAD+ bound to allosteric L-lactate dehydrogenase activated by chemical modification. Koide, S., Yokoyama, S., Matsuzawa, H., Miyazawa, T., Ohta, T. J. Biol. Chem. (1989)
- Rat kidney L-2-hydroxyacid oxidase. Structural and mechanistic comparison with flavocytochrome b2 from baker's yeast. Urban, P., Chirat, I., Lederer, F. Biochemistry (1988)
- Occurrence of the malate-aspartate shuttle in various tumor types. Greenhouse, W.V., Lehninger, A.L. Cancer Res. (1976)
- The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. Jackson, V.N., Halestrap, A.P. J. Biol. Chem. (1996)
- Evidence for distinct pathways in rabbit renal brush-border membrane vesicles for the transport of unsubstituted and alpha-hydroxysubstituted aliphatic monocarboxylic acids. Barbarat, B., Podevin, R.A. J. Biol. Chem. (1987)
- A 36-kilodalton tumor-derived factor with myeloid immunomodulatory activity. Packard, B.Z., Komoriya, A. J. Biol. Chem. (1993)
- L-lactate 2-monooxygenase from Mycobacterium smegmatis. Cloning, nucleotide sequence, and primary structure homology within an enzyme family. Giegel, D.A., Williams, C.H., Massey, V. J. Biol. Chem. (1990)
- A rabbit erythrocyte membrane protein associated with L-lactate transport. Jennings, M.L., Adams-Lackey, M. J. Biol. Chem. (1982)
- L(+)-Lactate binding to preparations of rat hepatocyte plasma membranes. Welch, S.G., Metcalfe, H.K., Monson, J.P., Cohen, R.D., Henderson, R.M., Iles, R.A. J. Biol. Chem. (1984)
- Demonstration of organic anion transport in T lymphocytes. L-lactate and fluo-3 are target molecules. Sommer, F., Bischof, S., Röllinghoff, M., Lohoff, M. J. Immunol. (1994)
- In vivo portal-hepatic venous gradients of glycogenic precursors and incorporation of D-[3-3H]glucose into liver glycogen in the awake rat. Dobson, G.P., Veech, R.L., Passonneau, J.V., Huang, M.T. J. Biol. Chem. (1990)
- Active site probes of flavoproteins. Determination of the solvent accessibility of the flavin position 8 for a series of flavoproteins. Schopfer, L.M., Massey, V., Claiborne, A. J. Biol. Chem. (1981)
- Stoichiometry of the renal sodium-L-lactate cotransporter. Barbarat, B., Podevin, R.A. J. Biol. Chem. (1988)
- Characterization of the enhanced transport of L- and D-lactate into human red blood cells infected with Plasmodium falciparum suggests the presence of a novel saturable lactate proton cotransporter. Cranmer, S.L., Conant, A.R., Gutteridge, W.E., Halestrap, A.P. J. Biol. Chem. (1995)
- Role of pyruvate kinase in the regulation of gluconeogenesis from L-lactate. Rognstad, R., Katz, J. J. Biol. Chem. (1977)
- Membrane-bound lactate dehydrogenases and mandelate dehydrogenases of Acinetobacter calcoaceticus. Purification and properties. Allison, N., O'Donnell, M.J., Fewson, C.A. Biochem. J. (1985)
- Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Hunt, T.K., Aslam, R.S., Beckert, S., Wagner, S., Ghani, Q.P., Hussain, M.Z., Roy, S., Sen, C.K. Antioxid. Redox Signal. (2007)
- Serial in vivo spectroscopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis. Provent, P., Benito, M., Hiba, B., Farion, R., López-Larrubia, P., Ballesteros, P., Rémy, C., Segebarth, C., Cerdán, S., Coles, J.A., García-Martín, M.L. Cancer Res. (2007)
- Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase. Richardson, M.C., Ingamells, S., Simonis, C.D., Cameron, I.T., Sreekumar, R., Vijendren, A., Sellahewa, L., Coakley, S., Byrne, C.D. J. Clin. Endocrinol. Metab. (2009)
- Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors. Zhang, M., White, T.A., Schuermann, J.P., Baban, B.A., Becker, D.F., Tanner, J.J. Biochemistry (2004)
- Isolation of the DLD gene of Saccharomyces cerevisiae encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase. Lodi, T., Ferrero, I. Mol. Gen. Genet. (1993)
- The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production. Ishida, N., Saitoh, S., Onishi, T., Tokuhiro, K., Nagamori, E., Kitamoto, K., Takahashi, H. Biosci. Biotechnol. Biochem. (2006)
- Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. Ritzhaupt, A., Wood, I.S., Ellis, A., Hosie, K.B., Shirazi-Beechey, S.P. J. Physiol. (Lond.) (1998)
- Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation. Erwin, A.L., Gotschlich, E.C. J. Bacteriol. (1996)
- Inhibitory effect of tumor cell-derived lactic acid on human T cells. Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., Renner, K., Timischl, B., Mackensen, A., Kunz-Schughart, L., Andreesen, R., Krause, S.W., Kreutz, M. Blood (2007)
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. Sonveaux, P., Végran, F., Schroeder, T., Wergin, M.C., Verrax, J., Rabbani, Z.N., De Saedeleer, C.J., Kennedy, K.M., Diepart, C., Jordan, B.F., Kelley, M.J., Gallez, B., Wahl, M.L., Feron, O., Dewhirst, M.W. J. Clin. Invest. (2008)
- Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. Liu, C., Wu, J., Zhu, J., Kuei, C., Yu, J., Shelton, J., Sutton, S.W., Li, X., Yun, S.J., Mirzadegan, T., Mazur, C., Kamme, F., Lovenberg, T.W. J. Biol. Chem. (2009)
- Evidence for a lactate-anion exchanger in the rat jejunal basolateral membrane. Cheeseman, C.I., Shariff, S., O'Neill, D. Gastroenterology (1994)
- Studies on the active center of D- and L-lactate dehydrogenases using oxamate-diaminohexyl-Sepharose affinity chromatography. Tuengler, P., Stein, T.N., Long, G.L. Proc. Natl. Acad. Sci. U.S.A. (1980)
- Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Borg, M.A., Tamborlane, W.V., Shulman, G.I., Sherwin, R.S. Diabetes (2003)
- Crystallization and preliminary crystallographic analysis at low resolution of the allosteric L-lactate dehydrogenase from Lactobacillus casei. Buehner, M., Hecht, H.J., Hensel, R., Mayr, U. J. Mol. Biol. (1982)