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Davis, J.M. et al.

Use of caffeine in the treatment of apnea associated with the Arnold-Chiari malformation.

The occurrence of significant apnea has been reported in infants with Arnold-Chiari malformation (ACM). We report 1 infant with ACM and severe apnea treated with caffeine therapy. There was a marked decrease in apnea frequency, less variability in breathing patterns, and a shift to the left of the CO2 response curve with caffeine. Our findings in 1 infant suggest that caffeine may be an effective adjunct in the treatment of apnea associated with ACM.[1]

References

Use of caffeine in the treatment of apnea associated with the Arnold-Chiari malformation. Davis, J.M., Zinman, R., Aranda, J.V. Developmental pharmacology and therapeutics. (1989) [Pubmed]

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