Influence of monosialoganglioside inner ester on neurologic recovery after global cerebral ischemia in monkeys.
We assessed the consequences of transitory global cerebral ischemia and the influence of monosialoganglioside inner ester ( AGF 2) treatment on neurologic outcome, cerebral blood flow, and cerebral metabolic rate in monkeys over 48 hours. Global cerebral ischemia was produced by a cervical tourniquet and a lowering of blood pressure to 6.65 kPa; recirculation followed after 30 minutes. AGF 2 (30 mg/kg) was administered intravenously immediately after initiation of recirculation and intramuscularly twice a day for 48 hours. Our results show that treatment with AGF 2 significantly accelerated the rate of neurologic recovery. Improvement was evident 5 hours after ischemia; full neurologic recovery was observed in half of the monkeys 48 hours after ischemia. This recovery was associated with a less severe reduction in cerebral blood flow without a concomitant increase in the cerebral metabolic rate.[1]References
- Influence of monosialoganglioside inner ester on neurologic recovery after global cerebral ischemia in monkeys. Cahn, R., Borzeix, M.G., Aldinio, C., Toffano, G., Cahn, J. Stroke (1989) [Pubmed]
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