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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Progesterone inhibits the uterotrophic effect of relaxin in immature rats.

Injection of progesterone for 3 days before treatment with relaxin inhibited the trophic effect of the peptide in both estrogen-primed and unprimed uteri. The depression in collagen concentration and increase in apparent rate of proline incorporation into collagen induced by relaxin alone were also eliminated, indicating a fundamental blockade of the effect of relaxin in this experimental design as well as a close association of changes in collagen concentration with tissue hypertrophy. The effect of relaxin on incorporation of proline into soluble protein was not blocked by progesterone, however, suggesting a separate mechanism for this anabolic effect of relaxin.[1]


  1. Progesterone inhibits the uterotrophic effect of relaxin in immature rats. Adams, W.C., Hanousek, C.A., Frieden, E.H. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
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