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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Murine complement component 3: genetic variation and linkage to H-2.

Two electrophoretic variants of murine complement component 3 (C3) were detected by using high-voltage electrophoresis of fresh mouse serum in agarose gels. Most of the inbred strains tested were homozygous for the S allele (for the slow-migrating variant); only four out of 46 strains had the alternative F allele (fast variant). Pen-bred Swiss-Webster animals belonged to one of three phenotypes--S, F, or SF--and the genes responsible for this variation segregated in a strictly Mendelian manner. In three such crosses, with 5* offspring, C3 segregated with H-2 in 46 instances, corresponding to a recombination frequency of approximately equal to 0.12.[1]


  1. Murine complement component 3: genetic variation and linkage to H-2. Da Silva, F.P., Hoecker, G.F., Day, N.K., Vienne, K., Rubinstein, P. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
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