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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Methylphenidate in amytal-resistant mutism.

Methylphenidate eliminated mutism in a catatonic schizophrenic after Amytal had failed. Response permitted an adequate clinical evaluation and temporary resumption of eating, self-care and sociability. This suggests that methylphenidate has a useful role in the clinical evaluation of the mute patient who fails to respond to Amytal and that 2 psychopharmacological varieties of catatonic mutism may exist.[1]


  1. Methylphenidate in amytal-resistant mutism. Frost, L.H. Acta psychiatrica Scandinavica. (1989) [Pubmed]
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