Studies on the genotoxicity of asataf (acephate), an organophosphate insecticide, in a mammalian in vivo system.
The genotoxic potential of asataf (acephate) was evaluated by a battery of in vivo tests: bone marrow chromosome aberrations, micronucleus, sperm-shape abnormality and dominant lethal tests in mice. A significant enhancement in the percentage of chromosome aberrations was noticed in 3 doses, 3 routes and 3 h after asataf treatment of groups of mice as well as in chronic (sub-acute) treatment. A significant difference in the occurrence of micronuclei was found only at the highest dose whereas all the results of the sperm-shape abnormality test were highly significant. In the dominant lethal mutagenicity assay only the result (dead implants) of a single week (3rd) with the higher dose differed significantly from control. On the basis of the present in vivo results in mouse test systems asataf may be considered to be a potential mutagen.[1]References
- Studies on the genotoxicity of asataf (acephate), an organophosphate insecticide, in a mammalian in vivo system. Behera, B.C., Bhunya, S.P. Mutat. Res. (1989) [Pubmed]
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