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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina.

Synthesis and storage of [3H]acetylcholine in isolated pieces of chick retina increased in two stages during embryogenesis. The first increase coincided with a 100-fold rise in the activity of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), but during the second increase the activity of this enzyme remained essentially constant. The second increase instead was linked to an approximately 6-fold increase in the Vmax for high-affinity uptake of choline.[1]

References

  1. Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina. Bader, C.R., Baughman, R.W., Moore, J.L. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
 
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