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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Heritable fraction of unilateral Wilms tumor.

Heritability of the unilateral-sporadic (non-familial) form of Wilms tumor was examined in the offspring of 96 long-term survivors of the neoplasm. No Wilms tumor has developed in any of the 179 offspring of these patients. The maximum likelihood estimate of a hereditary Wilms tumor in our patients is zero and the corresponding 95% upper confidence limit ranges between 0.06 and 0.11, depending on penetrance. Among their offspring, the 95% upper bound of the risk of Wilms tumor is 0.02. These figures can be applied in genetic counseling of other survivors of unilateral-sporadic Wilms tumor.[1]


  1. Heritable fraction of unilateral Wilms tumor. Li, F.P., Williams, W.R., Gimbrere, K., Flamant, F., Green, D.M., Meadows, A.T. Pediatrics (1988) [Pubmed]
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