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Sims, S.M. et al.

Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells.

The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.[1]

References

Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells. Sims, S.M., Singer, J.J., Walsh, J.V. Science (1988) [Pubmed]

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