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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Binding profile of trazodone and dapiprazole to some brain receptors.

Trazodone and dapiprazole displace ligands binding to rat brain alpha-1 adrenoceptors. The displacement of 3H-ligands to alpha-2, serotonin1 (5-HT1), dopamine, beta and opiate receptors is either absent or takes place at relatively higher concentrations. Trazodone, unlike dapiprazole, also inhibits binding to serotonin2 (5-HT2) receptors. Some pharmacological effects show a satisfactory correlation with these data. The psychopharmacological effects of trazodone and dapiprazole are similar, whereas the binding inhibition to 5-HT2 receptors is different, which would indicate that the psychopharmacological effects do not primarily depend on these receptors. The displacement of the binding to alpha-1 adrenoceptors by dapiprazole has a time course similar to that of its brain concentrations as well as to that of sedative and alpha-blocking effects. Dapiprazole and trazodone have antinociceptive effects and inhibit the binding to opiate receptors, although at relatively high concentrations.[1]


  1. Binding profile of trazodone and dapiprazole to some brain receptors. Valeri, P., Palmery, M., Silvestrini, B. Drugs under experimental and clinical research. (1988) [Pubmed]
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