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Chemical Compound Review

Thombran     8-[3-[4-(3- chlorophenyl)piperazin-1...

Synonyms: Trazalon, Trazodil, Trazodon, Trazolan, Trittico, ...
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Disease relevance of Desyrel


Psychiatry related information on Desyrel


High impact information on Desyrel


Chemical compound and disease context of Desyrel


Biological context of Desyrel


Anatomical context of Desyrel

  • RESULTS: Formation of mCPP from trazodone in liver microsomes had a mean (+/- SE) K(m) value of 163 (+/- 21) micromol/L [19].
  • Among heterologously expressed human cytochromes, only CYP3A4 mediated formation of mCPP from trazodone; the K(m) was 180 micromol/L, consistent with the value in microsomes [19].
  • Trazodone, its active metabolite 1-(m-chlorophenyl)piperazine (mCPP) and two isomers of mCPP were tested for affinity to the binding sites for [3H]flunitrazepam ([3H]FLU) and [3H]p-aminoclonidine ([3H]pAC) in the frontal cortex, amygdala and hippocampus of the rat [24].
  • Comparative effects of trazodone and tricyclic antidepressants on uptake of selected neurotransmitters by isolated rat brain synaptosomes [25].
  • Intracavernosal trazodone results in erectile activity that appears in part based on its local alpha blocking activity but like other intracavernosal alpha-blocking agents is not as effective in initiating penile erections as are intracavernosal agents that directly induce smooth muscle relaxation [26].

Associations of Desyrel with other chemical compounds


Gene context of Desyrel


Analytical, diagnostic and therapeutic context of Desyrel


  1. Treatment of painful diabetic neuropathy with trazodone. Khurana, R.C. JAMA (1983) [Pubmed]
  2. Trazodone in essential tremor. McLeod, N.A., White, L.E. JAMA (1986) [Pubmed]
  3. Trazodone associated with priapism. Aronoff, G.M. Lancet (1984) [Pubmed]
  4. Trazodone and liver toxicity. Chu, A.G., Gunsolly, B.L., Summers, R.W., Alexander, B., McChesney, C., Tanna, V.L. Ann. Intern. Med. (1983) [Pubmed]
  5. Chronic active hepatitis associated with trazodone therapy. Beck, P.L., Bridges, R.J., Demetrick, D.J., Kelly, J.K., Lee, S.S. Ann. Intern. Med. (1993) [Pubmed]
  6. Trazodone treatment of obsessive-compulsive disorder and trichotillomania. Sunkureddi, K., Markovitz, P. The American journal of psychiatry. (1993) [Pubmed]
  7. Increased libido with trazodone. Sullivan, G. The American journal of psychiatry. (1987) [Pubmed]
  8. Trazodone in the treatment of panic disorder and agoraphobia with panic attacks. Mavissakalian, M., Perel, J., Bowler, K., Dealy, R. The American journal of psychiatry. (1987) [Pubmed]
  9. Trazodone-induced mania following desipramine-induced mania in major depressive disorders. Arana, G.W., Kaplan, G.B. The American journal of psychiatry. (1985) [Pubmed]
  10. Effects of trazodone on aggressive behavior in seven patients with organic mental disorders. Pinner, E., Rich, C.L. The American journal of psychiatry. (1988) [Pubmed]
  11. Trazodone-oral cocaine interactions. Rowbotham, M.C., Jones, R.T., Benowitz, N.L., Jacob, P. Arch. Gen. Psychiatry (1984) [Pubmed]
  12. Trazodone and intrahepatic cholestasis. Sheikh, K.H., Nies, A.S. Ann. Intern. Med. (1983) [Pubmed]
  13. Sleep apnea in olivopontocerebellar degeneration: treatment with trazodone. Salazar-Grueso, E.F., Rosenberg, R.S., Roos, R.P. Ann. Neurol. (1988) [Pubmed]
  14. Agranulocytosis probably induced by trazodone. Van der Klauw, M.M., Janssen, J.C., Stricker, B.H. The American journal of psychiatry. (1993) [Pubmed]
  15. Trazodone induction of migraine headache through mCPP. Workman, E.A., Tellian, F., Short, D. The American journal of psychiatry. (1992) [Pubmed]
  16. A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease. Lawlor, B.A., Sunderland, T., Mellow, A.M., Molchan, S.E., Martinez, R., Murphy, D.L. Biol. Psychiatry (1991) [Pubmed]
  17. Failure of central nervous system serotonin blockage to influence outcome in acute cerebral infarction. A double blind randomized trial. Ramirez-Lessepas, M., Patrick, B.K., Snyder, B.D., Lakatua, D.J. Stroke (1986) [Pubmed]
  18. The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog. Veasey, S.C., Fenik, P., Panckeri, K., Pack, A.I., Hendricks, J.C. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  19. In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors. Zalma, A., von Moltke, L.L., Granda, B.W., Harmatz, J.S., Shader, R.I., Greenblatt, D.J. Biol. Psychiatry (2000) [Pubmed]
  20. Epilepsy and sleep apnea syndrome. Devinsky, O., Ehrenberg, B., Barthlen, G.M., Abramson, H.S., Luciano, D. Neurology (1994) [Pubmed]
  21. [3H]tetrahydrotrazodone binding. Association with serotonin binding sites. Kendall, D.A., Taylor, D.P., Enna, S.J. Mol. Pharmacol. (1983) [Pubmed]
  22. Trazodone kinetics: effect of age, gender, and obesity. Greenblatt, D.J., Friedman, H., Burstein, E.S., Scavone, J.M., Blyden, G.T., Ochs, H.R., Miller, L.G., Harmatz, J.S., Shader, R.I. Clin. Pharmacol. Ther. (1987) [Pubmed]
  23. Trazodone dosing regimen: experience with single daily administration. Fabre, L.F. The Journal of clinical psychiatry. (1990) [Pubmed]
  24. Trazodone and m-chlorophenylpiperazine. Concentration in brain and receptor activity in regions in the brain associated with anxiety. Smith, T.M., Suckow, R.F. Neuropharmacology (1985) [Pubmed]
  25. Comparative effects of trazodone and tricyclic antidepressants on uptake of selected neurotransmitters by isolated rat brain synaptosomes. Riblet, L.A., Gatewood, C.F., Mayol, R.F. Psychopharmacology (Berl.) (1979) [Pubmed]
  26. Effects of intracavernosal trazodone hydrochloride: animal and human studies. Azadzoi, K.M., Payton, T., Krane, R.J., Goldstein, I. J. Urol. (1990) [Pubmed]
  27. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Teri, L., Logsdon, R.G., Peskind, E., Raskind, M., Weiner, M.F., Tractenberg, R.E., Foster, N.L., Schneider, L.S., Sano, M., Whitehouse, P., Tariot, P., Mellow, A.M., Auchus, A.P., Grundman, M., Thomas, R.G., Schafer, K., Thal, L.J. Neurology (2000) [Pubmed]
  28. A comparative trial of fluoxetine versus trazodone in outpatients with major depression. Perry, P.J., Garvey, M.J., Kelly, M.W., Cook, B.L., Dunner, F.J., Winokur, G. The Journal of clinical psychiatry. (1989) [Pubmed]
  29. Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion. Maes, M., Song, C., Lin, A.H., Bonaccorso, S., Kenis, G., De Jongh, R., Bosmans, E., Scharpé, S. Neuropsychopharmacology (1999) [Pubmed]
  30. Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Rotzinger, S., Fang, J., Baker, G.B. Drug Metab. Dispos. (1998) [Pubmed]
  31. Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats. Balsara, J.J., Jadhav, S.A., Gaonkar, R.K., Gaikwad, R.V., Jadhav, J.H. Psychopharmacology (Berl.) (2005) [Pubmed]
  32. Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine. Mihara, K., Otani, K., Suzuki, A., Yasui, N., Nakano, H., Meng, X., Ohkubo, T., Nagasaki, T., Kaneko, S., Tsuchida, S., Sugawara, K., Gonzalez, F.J. Psychopharmacology (Berl.) (1997) [Pubmed]
  33. A comparison of the effects of trazodone and amitriptyline on skills performance by geriatric subjects. Burns, M., Moskowitz, H., Jaffe, J. The Journal of clinical psychiatry. (1986) [Pubmed]
  34. Plasma trazodone concentrations and clinical response in elderly depressed patients: a preliminary study. Monteleone, P., Gnocchi, G., Delrio, G. Journal of clinical psychopharmacology. (1989) [Pubmed]
  35. ECG findings in geriatric depressives given trazodone, placebo, or imipramine. Hayes, R.L., Gerner, R.H., Fairbanks, L., Moran, M., Waltuch, L. The Journal of clinical psychiatry. (1983) [Pubmed]
  36. Trazodone and hemodialysis. Doweiko, J., Fogel, B.S., Goldberg, R.J. The Journal of clinical psychiatry. (1984) [Pubmed]
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