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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of lidamidine, a proposed alpha 2-adrenoreceptor agonist, on salt and water transport in human jejunum.

The effects of a new antidiarrheal agent, lidamidine (10 mg per os) and an identical placebo on jejunal fluid and electrolyte transport in vivo were investigated in five normal volunteers during steady-state perfusion of a 25-cm length of jejunum with a plasma-like solution. Studies were carried out under basal conditions and during secretion stimulated by incorporation of prostaglandin E2 (5 X 10(-6) M) in the infusate. Lidamidine had no significant effect on jejunal fluid transport under basal conditions but reduced secretion induced by prostaglandin E2 (P less than 0.05).[1]

References

  1. Effect of lidamidine, a proposed alpha 2-adrenoreceptor agonist, on salt and water transport in human jejunum. Edwards, C.A., Read, N.W. Dig. Dis. Sci. (1986) [Pubmed]
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