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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mediation of separation distress by alpha 2-adrenergic mechanisms in a non-human primate.

This study provides the first behavioral evidence in support of an alpha-adrenergic mechanism underlying imipramine's amelioration of separation distress. The rate of separation-induced vocalization by adult squirrel monkeys was decreased by imipramine and the alpha 2-adrenergic agonist clonidine, and increased by the alpha 2-adrenergic antagonist yohimbine. Yohimbine, but not the alpha 1-antagonist prazosin, reversed the clonidine effect suggesting that drugs acting directly on alpha 2-receptors may have a role in management of separation anxiety.[1]


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