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MeSH Review

Anxiety, Separation

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Psychiatry related information on Anxiety, Separation


High impact information on Anxiety, Separation

  • In children of normal intelligence, parenchymal lesions/ventricular enlargement independently increased risk for any disorder (OR, 4.8; CI, 1.6-12.0; P < .01), attention deficit hyperactivity disorder (OR, 4.5; CI, 1.3-16.0; P = .02), and separation anxiety (OR, 5.3; CI, 1.1-24.8; P = .03) [6].
  • Panic disorder in the parents conferred more than a threefold increased risk of separation anxiety in the children [7].
  • However, many aspects of the mechanisms that establish and maintain cohesion during mitosis remain unclear.RESULTS: We found that mutations in two evolutionarily conserved Drosophila genes, san (separation anxiety) and deco (Drosophila eco1), disrupt centromeric sister chromatid cohesion very early in division [8].
  • Fifty-nine subjects 5-16 years old with major depressive disorder were assessed for the presence of separation anxiety and antisocial behavior, mentioned in DSM-III as associated features of the disorder in children and adolescents [9].
  • Among 56 persons who were acutely bereaved or threatened with a loss, a group with worsening separation anxiety over a period of a month early after the event had higher urinary free cortisol output than a group experiencing improvement in grief [10].

Chemical compound and disease context of Anxiety, Separation


Biological context of Anxiety, Separation


Gene context of Anxiety, Separation

  • Obsessive-compulsive disorder and separation anxiety [17].
  • METHOD: A two-sample comparative design was employed so that a clinical group of adolescents were compared with a matched non-clinical group, on attachment classifications (using a modified Separation Anxiety Test), reported interpersonal difficulties and clinical symptoms [18].
  • We found that our two measures of psychological distress, both separation anxiety and depression, were directly correlated with prolactin response during a stressful interview (p less than .05) [19].
  • The hypothesis that mothers of children who have symptoms indicative of separation anxiety are themselves separation-anxious was tested by scoring mothers' TAT themes for separation concerns [20].
  • Cortisols differed significantly by ANOVA among principal diagnoses, with highest values in children with major depression (MDE) or separation anxiety (SAD) and lowest in those with behavior disorders (BD) [21].


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  5. Obsessive-compulsive disorder and separation anxiety co-morbidity in early onset panic disorder. Goodwin, R., Lipsitz, J.D., Chapman, T.F., Mannuzza, S., Fyer, A.J. Psychological medicine. (2001) [Pubmed]
  6. Psychiatric outcomes in low-birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities. Whitaker, A.H., Van Rossem, R., Feldman, J.F., Schonfeld, I.S., Pinto-Martin, J.A., Tore, C., Shaffer, D., Paneth, N. Arch. Gen. Psychiatry (1997) [Pubmed]
  7. Depression and anxiety disorders in parents and children. Results from the Yale family study. Weissman, M.M., Leckman, J.F., Merikangas, K.R., Gammon, G.D., Prusoff, B.A. Arch. Gen. Psychiatry (1984) [Pubmed]
  8. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Williams, B.C., Garrett-Engele, C.M., Li, Z., Williams, E.V., Rosenman, E.D., Goldberg, M.L. Curr. Biol. (2003) [Pubmed]
  9. Preliminary data on DSM-III associated features of major depressive disorder in children and adolescents. Geller, B., Chestnut, E.C., Miller, M.D., Price, D.T., Yates, E. The American journal of psychiatry. (1985) [Pubmed]
  10. Urinary free cortisol and separation anxiety early in the course of bereavement and threatened loss. Jacobs, S.C., Mason, J., Kosten, T.R., Kasl, S.V., Ostfeld, A.M., Wahby, V. Biol. Psychiatry (1987) [Pubmed]
  11. Fluoxetine for childhood anxiety disorders. Birmaher, B., Waterman, G.S., Ryan, N., Cully, M., Balach, L., Ingram, J., Brodsky, M. Journal of the American Academy of Child and Adolescent Psychiatry. (1994) [Pubmed]
  12. A placebo-controlled comparison between betamethasone and dexamethasone for fetal maturation: differences in neurobehavioral development of mice offspring. Rayburn, W.F., Christensen, H.D., Gonzalez, C.L. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  13. Mediation of separation distress by alpha 2-adrenergic mechanisms in a non-human primate. Harris, J.C., Newman, J.D. Brain Res. (1987) [Pubmed]
  14. Separation anxiety in children and adolescents treated with risperidone. Hanna, G.L., Fluent, T.E., Fischer, D.J. Journal of child and adolescent psychopharmacology. (1999) [Pubmed]
  15. Buspirone in the treatment of separation anxiety in an adolescent boy. Balon, R. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1994) [Pubmed]
  16. Treatment of pediatric anxiety disorders: an open-label extension of the research units on pediatric psychopharmacology anxiety study. Walkup, J., Labellarte, M., Riddle, M.A., Pine, D.S., Greenhill, L., Fairbanks, J., Klein, R., Davies, M., Sweeney, M., Abikoff, H., Hack, S., Klee, B., Bergman, R.L., Lynn, D., McCracken, J., March, J., Gammon, P., Vitiello, B., Ritz, L., Roper, M. Journal of child and adolescent psychopharmacology. (2002) [Pubmed]
  17. Obsessive-compulsive disorder and separation anxiety. Bryńska, A., Wolańczyk, T. Journal of the American Academy of Child and Adolescent Psychiatry. (1998) [Pubmed]
  18. The relationship between attachment strategies and psychopathology in adolescence. Brown, L.S., Wright, J. Psychology and psychotherapy. (2003) [Pubmed]
  19. Psychological distress, depression and prolactin response in stressed persons. Jacobs, S., Brown, S.A., Mason, J., Wahby, V., Kasl, S., Ostfeld, A. Journal of human stress. (1986) [Pubmed]
  20. Separation anxiety in mothers of latency-age fearful children. Breit, M. Journal of abnormal child psychology. (1982) [Pubmed]
  21. Depression, anxiety and the dexamethasone suppression test in hospitalized prepubertal children. Livingston, R., Martin-Cannici, C. The Hillside journal of clinical psychiatry. (1987) [Pubmed]
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