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Methyprylon-induced bone marrow suppression in siblings. An inherited defect?

Transient bone marrow suppression in two sisters followed ingestion of the sedative-hypnotic drug methyprylon. No other pharmacologic or environmental inciting factor common to both patients was identified. The mechanisms responsible could not be defined; abnormal suppression fo granulocyte progenitors by the drug in vitro was not demonstrable. It is postulated that a pharmacogenetic interaction may have been responsible for methyprylon-related bone marrow suppression in these two siblings.[1]


  1. Methyprylon-induced bone marrow suppression in siblings. An inherited defect? McLaren, G.D., Doukas, M.A., Muir, W.A. JAMA (1978) [Pubmed]
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