Disease relevance of Methyprolon

• Image of the month. Nodular fatty infiltration of the liver in Wilson's disease [1].
• CONCLUSIONS: Nodular lymphangitis has distinctive clinical signs and symptoms, most commonly due to infection with a limited number of organisms [2].
• DATA SYNTHESIS: Nodular lymphangitis develops most commonly after cutaneous inoculation with Sporothrix schenckii, Nocardia brasiliensis, Mycobacterium marinum, Leishmania braziliensis, and Francisella tularensis [2].
• Our results were as follows: diffuse (n = 4) and nodular (n = 1) adrenal hyperplasia in patients with ACTH-dependent Cushing's syndrome, polyclonal pattern; adrenocortical adenomas (n = 8), monoclonal (n = 7), as well as polyclonal (n = 1); adrenal carcinomas (n = 3), monoclonal pattern [3].
• A B cell origin was found in 17 adults classified as having nodular (N) or diffuse (D) poorly differentiated lymphocytic lymphoma (PDLL) [4].

High impact information on Methyprolon

• Methyprylon-induced bone marrow suppression in siblings. An inherited defect [5]?
• Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture [6].
• BACKGROUND/AIMS: Nodular regenerative hyperplasia of the liver is a histological lesion usually associated with systemic diseases, haematological malignancies, or drugs [7].
• Interestingly, long-term serum intact iPTH levels were higher in patients with nodular (N = 18) than with diffusely (N = 26) hyperplastic glands: 556 +/- 146 versus 126 +/- 52 pg/mL (P < 0.001) and recurrence of hyperparathyroidism was more frequent with nodular hyperplasia (11 of 18) than with diffuse hyperplasia (4 of 26) (P < 0.02) [8].
• 2. Nodular regenerative hyperplasia occurred in livers which had widespread obliteration of portal vein radicals (obliterative portal venopathy) [9].

Chemical compound and disease context of Methyprolon

• Interpretation of blood glutethimide, meprobamate, and methyprylon concentrations in nonfatal and fatal intoxications involving a single drug [10].
• CONTEXT: Nodular hyperplasia (also referred to as nodular regenerative hyperplasia and nodular regenerative hyperplasia of the liver) is a sequel to therapy with thioguanine in patients with hematologic malignancies [11].

Biological context of Methyprolon

• These results indicate that the pharmacokinetics of methyprylon are nonlinear (concentration dependent) in this overdosed patient; explanations include saturation of one or more of the metabolic pathways and/or product inhibition [12].
• Patients with Nodular Sclerosis histology are more likely to relapse than those with other histologies [13].
• Images in clinical medicine. Nodular sarcoidosis [14].
• Diagnostic ophthalmology. Nodular iris melanoma of the right eye [15].

Anatomical context of Methyprolon

• METHODS: Nodular thyroid lesions in 11 patients were evaluated before surgical resection [16].
• CONCLUSION: Nodular and tubular structures in the mediastinum and around the central airway on thin-section CT scans in the patients with bronchiectasis are suggestive of hypertrophied bronchial arteries [17].
• A Double-Positive CD4+CD8+ T-Cell Population Is Commonly Found in Nodular Lymphocyte Predominant Hodgkin Lymphoma [18].
• The lesions presented as a polypoid (n = 10) or nodular (n = 4) mass in the vagina (n = 12) or cervix (n = 2) of women ranging in age from 40 to 74 years (median, 58 years) [19].
• The diffuse-only pattern occurred in mixed cellularity with abundant fibrohistiocytoid stromal cells (n = 2) [20].

Associations of Methyprolon with other chemical compounds

• Determination of methyprylon and its dehydro metabolite, 5-methylpyrithyldione, in plasma by high-performance liquid chromatography [21].

Gene context of Methyprolon

• Unusual and memorable. Nodular erosive rheumatoid arthritis [22].
• A waxy plaque on the leg. Nodular or tumefactive cutaneous amyloidosis (NCA) [23].
• CONCLUSION: Nodular enhancement is the predominant enhancement pattern for new MS lesions, and the temporal course of enhancement is usually shorter than 6 months [24].
• METHODS: Nodular lesions detected by laparoscopic US in 186 patients with hepatocellular carcinoma were examined and we evaluated the diagnostic ability of laparoscopic US to detect multicentric hepatocellular carcinoma [25].
• Each prognostic subgroup demonstrated an immunohistochemically distinct pattern of stromal cell composition in the neuroblastic elements: Type A Intermixed had numerous S-100 cells and no FER cells, Type B Intermixed contained many S-100 cells and a moderate number of FER cells, and Nodular had few S-100 cells with many FER cells [26].

Analytical, diagnostic and therapeutic context of Methyprolon

• Hemodialysis in methyprylon overdose. Some pharmacokinetic considerations [27].
• Peritoneal dialysis for methyprylon intoxication [28].
• Plasma concentrations of methyprylon and its dehydro metabolite were measured using a recently developed HPLC assay [29].
• The rate of disappearance of N type BM mets after chemotherapy was 100% (7/7) and was significantly higher than that (26%, 10/38) of D type BM mets [30].
• RESULTS: Nodular goiter was detected in 52.8% (47/89) of the CAPD patients [31].

References