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Chemical Compound Review

Dimerin     3,3-diethyl-5-methyl- piperidine-2,4-dione

Synonyms: Nodular, Noludar, Methprylon, Metiprilon, Noctan, ...
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Disease relevance of Methyprolon


High impact information on Methyprolon

  • Methyprylon-induced bone marrow suppression in siblings. An inherited defect [5]?
  • Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture [6].
  • BACKGROUND/AIMS: Nodular regenerative hyperplasia of the liver is a histological lesion usually associated with systemic diseases, haematological malignancies, or drugs [7].
  • Interestingly, long-term serum intact iPTH levels were higher in patients with nodular (N = 18) than with diffusely (N = 26) hyperplastic glands: 556 +/- 146 versus 126 +/- 52 pg/mL (P < 0.001) and recurrence of hyperparathyroidism was more frequent with nodular hyperplasia (11 of 18) than with diffuse hyperplasia (4 of 26) (P < 0.02) [8].
  • 2. Nodular regenerative hyperplasia occurred in livers which had widespread obliteration of portal vein radicals (obliterative portal venopathy) [9].

Chemical compound and disease context of Methyprolon


Biological context of Methyprolon


Anatomical context of Methyprolon

  • METHODS: Nodular thyroid lesions in 11 patients were evaluated before surgical resection [16].
  • CONCLUSION: Nodular and tubular structures in the mediastinum and around the central airway on thin-section CT scans in the patients with bronchiectasis are suggestive of hypertrophied bronchial arteries [17].
  • A Double-Positive CD4+CD8+ T-Cell Population Is Commonly Found in Nodular Lymphocyte Predominant Hodgkin Lymphoma [18].
  • The lesions presented as a polypoid (n = 10) or nodular (n = 4) mass in the vagina (n = 12) or cervix (n = 2) of women ranging in age from 40 to 74 years (median, 58 years) [19].
  • The diffuse-only pattern occurred in mixed cellularity with abundant fibrohistiocytoid stromal cells (n = 2) [20].

Associations of Methyprolon with other chemical compounds


Gene context of Methyprolon

  • Unusual and memorable. Nodular erosive rheumatoid arthritis [22].
  • A waxy plaque on the leg. Nodular or tumefactive cutaneous amyloidosis (NCA) [23].
  • CONCLUSION: Nodular enhancement is the predominant enhancement pattern for new MS lesions, and the temporal course of enhancement is usually shorter than 6 months [24].
  • METHODS: Nodular lesions detected by laparoscopic US in 186 patients with hepatocellular carcinoma were examined and we evaluated the diagnostic ability of laparoscopic US to detect multicentric hepatocellular carcinoma [25].
  • Each prognostic subgroup demonstrated an immunohistochemically distinct pattern of stromal cell composition in the neuroblastic elements: Type A Intermixed had numerous S-100 cells and no FER cells, Type B Intermixed contained many S-100 cells and a moderate number of FER cells, and Nodular had few S-100 cells with many FER cells [26].

Analytical, diagnostic and therapeutic context of Methyprolon


  1. Image of the month. Nodular fatty infiltration of the liver in Wilson's disease. Pascual, S., Such, J., Quilez, C. Gastroenterology (2002) [Pubmed]
  2. Nodular lymphangitis: a distinctive but often unrecognized syndrome. Kostman, J.R., DiNubile, M.J. Ann. Intern. Med. (1993) [Pubmed]
  3. Clonal composition of human adrenocortical neoplasms. Beuschlein, F., Reincke, M., Karl, M., Travis, W.D., Jaursch-Hancke, C., Abdelhamid, S., Chrousos, G.P., Allolio, B. Cancer Res. (1994) [Pubmed]
  4. B and T cell lymphomas. Analysis of blood and lymph nodes in 87 patients. Gajl-Peczalska, K.J., Bloomfield, C.D., Coccia, P.F., Sosin, H., Brunning, R.D., Kersey, J.H. Am. J. Med. (1975) [Pubmed]
  5. Methyprylon-induced bone marrow suppression in siblings. An inherited defect? McLaren, G.D., Doukas, M.A., Muir, W.A. JAMA (1978) [Pubmed]
  6. Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. Sterzel, R.B., Lovett, D.H., Foellmer, H.G., Perfetto, M., Biemesderfer, D., Kashgarian, M. Am. J. Pathol. (1986) [Pubmed]
  7. Familial occurrence of nodular regenerative hyperplasia of the liver: a report on three families. Dumortier, J., Boillot, O., Chevallier, M., Berger, F., Potier, P., Valette, P.J., Paliard, P., Scoazec, J.Y. Gut (1999) [Pubmed]
  8. Short- and long-term efficacy of total parathyroidectomy with immediate autografting compared with subtotal parathyroidectomy in hemodialysis patients. Gagné, E.R., Ureña, P., Leite-Silva, S., Zingraff, J., Chevalier, A., Sarfati, E., Dubost, C., Drüeke, T.B. J. Am. Soc. Nephrol. (1992) [Pubmed]
  9. Nodular regenerative hyperplasia of the liver in hematologic disorders: a possible response to obliterative portal venopathy. A morphometric study of nine cases with an hypothesis on the pathogenesis. Wanless, I.R., Godwin, T.A., Allen, F., Feder, A. Medicine (Baltimore) (1980) [Pubmed]
  10. Interpretation of blood glutethimide, meprobamate, and methyprylon concentrations in nonfatal and fatal intoxications involving a single drug. Bailey, D.N., Shaw, R.F. J. Toxicol. Clin. Toxicol. (1983) [Pubmed]
  11. Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy. Shastri, S., Dubinsky, M.C., Fred Poordad, F., Vasiliauskas, E.A., Geller, S.A. Arch. Pathol. Lab. Med. (2004) [Pubmed]
  12. Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration. Contos, D.A., Dixon, K.F., Guthrie, R.M., Gerber, N., Mays, D.C. Journal of pharmaceutical sciences. (1991) [Pubmed]
  13. Patterns of relapse in advanced Hodgkin's disease treated with combination chemotherapy. Young, R.C., Canellos, G.P., Chabner, B.A., Hubbard, S.M., DeVita, V.T. Cancer (1978) [Pubmed]
  14. Images in clinical medicine. Nodular sarcoidosis. McCullough, P.C., McCullough, A.E. N. Engl. J. Med. (2002) [Pubmed]
  15. Diagnostic ophthalmology. Nodular iris melanoma of the right eye. Grahn, B.H., Cullen, C.L. Can. Vet. J. (2005) [Pubmed]
  16. Fluorine-18-fluorodeoxyglucose PET versus thallium-201 scintigraphy evaluation of thyroid tumors. Uematsu, H., Sadato, N., Ohtsubo, T., Tsuchida, T., Nakamura, S., Sugimoto, K., Waki, A., Takahashi, N., Yonekura, Y., Tsuda, G., Saito, H., Hayashi, N., Yamamoto, K., Ishii, Y. J. Nucl. Med. (1998) [Pubmed]
  17. Hypertrophied bronchial artery at thin-section CT in patients with bronchiectasis: correlation with CT angiographic findings. Song, J.W., Im, J.G., Shim, Y.S., Park, J.H., Yeon, K.M., Han, M.C. Radiology. (1998) [Pubmed]
  18. A Double-Positive CD4+CD8+ T-Cell Population Is Commonly Found in Nodular Lymphocyte Predominant Hodgkin Lymphoma. Rahemtullah, A., Reichard, K.K., Preffer, F.I., Harris, N.L., Hasserjian, R.P. Am. J. Clin. Pathol. (2006) [Pubmed]
  19. Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Laskin, W.B., Fetsch, J.F., Tavassoli, F.A. Hum. Pathol. (2001) [Pubmed]
  20. Expression of cell adhesion molecules associated with germinal center in Hodgkin's disease: an immunohistochemical study. The germinal center related complex and histologic subtypes. Ree, H.J., Khan, A.A., Qureshi, M.N., Teplitz, C. Cancer (1994) [Pubmed]
  21. Determination of methyprylon and its dehydro metabolite, 5-methylpyrithyldione, in plasma by high-performance liquid chromatography. Pankaskie, M.C., Brooks, M.A. J. Chromatogr. (1983) [Pubmed]
  22. Unusual and memorable. Nodular erosive rheumatoid arthritis. Ehrenfeld, M., Gur, H. Ann. Rheum. Dis. (1998) [Pubmed]
  23. A waxy plaque on the leg. Nodular or tumefactive cutaneous amyloidosis (NCA). Tuneu, A., Pujol, R.M. Archives of dermatology. (1988) [Pubmed]
  24. Enhancing patterns in multiple sclerosis: evolution and persistence. He, J., Grossman, R.I., Ge, Y., Mannon, L.J. AJNR. American journal of neuroradiology. (2001) [Pubmed]
  25. The role of laparoscopic US and laparoscopic US-guided aspiration biopsy in the diagnosis of multicentric hepatocellular carcinoma. Ido, K., Nakazawa, Y., Isoda, N., Kawamoto, C., Nagamine, N., Ono, K., Hozumi, M., Sato, Y., Kimura, K., Sugano, K. Gastrointest. Endosc. (1999) [Pubmed]
  26. Histopathologic features of composite ganglioneuroblastoma. Immunohistochemical distinction of the stromal component is related to prognosis. Aoyama, C., Qualman, S.J., Regan, M., Shimada, H. Cancer (1990) [Pubmed]
  27. Hemodialysis in methyprylon overdose. Some pharmacokinetic considerations. Pancorbo, A.S., Palagi, P.A., Piecoro, J.J., Wilson, H.D. JAMA (1977) [Pubmed]
  28. Peritoneal dialysis for methyprylon intoxication. Collins, J.M. J. Pediatr. (1978) [Pubmed]
  29. Pharmacokinetics of methyprylon following a single oral dose. Gwilt, P.R., Pankaskie, M.C., Thornburg, J.E., Zustiak, R., Shoenthal, D.R. Journal of pharmaceutical sciences. (1985) [Pubmed]
  30. Bone marrow metastasis of neuroblastoma analyzed by MRI and its influence on prognosis. Tanabe, M., Ohnuma, N., Iwai, J., Yoshida, H., Takahashi, H., Maie, M., Etoh, T., Kawamura, K. Med. Pediatr. Oncol. (1995) [Pubmed]
  31. Association of anion gap with thyroid dysfunction and nodular goiter in CAPD patients. Lin, C.C., Yang, W.C., Ng, Y.Y., Chou, Y.H., Tarng, D.C., Chen, T.W. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2002) [Pubmed]
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