Measles virus editing provides an additional cysteine-rich protein.
The measles virus (MV) phosphoprotein ( P) gene encodes two known proteins, P (Mr approximately 70,000), involved in viral transcription, and, in a different reading frame, C (Mr approximately 20,000). By a combination of cDNA cloning, cDNA and RNA sequencing, and in vitro translation, we demonstrate here that the MV P gene also expresses a third product (Mr approximately 46,000) containing the amino-terminal region of P but a different, cysteine-rich carboxy-terminal motif. This third protein is translated from mRNAs in which one G residue has been inserted after three genomically encoded Gs, a modification found in about 50% of the P mRNAs. A smaller fraction of transcripts contain several additional G residues.[1]References
- Measles virus editing provides an additional cysteine-rich protein. Cattaneo, R., Kaelin, K., Baczko, K., Billeter, M.A. Cell (1989) [Pubmed]
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