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P/V/C  -  subunit of RNA dependent RNA polymerase...

Measles virus

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Disease relevance of P

  • RNA interference with measles virus N, P, and L mRNAs efficiently prevents and with matrix protein mRNA enhances viral transcription [1].
  • The P gene was shown to have the capacity to encode three distinct proteins, P, V and C, in analogy to other morbilliviruses [2].
  • When the nucleotide and deduced amino acid sequences of the N, P, V and C genes were aligned with corresponding sequences of other established members of the morbillivirus genus, compelling homology was found between PDV and canine distemper virus (CDV), whereas there was markedly less similarity between PDV and measles virus or rinderpest virus [2].
  • CONCLUSIONS: This study shows that discrimination between SSPE and MS can be achieved in doubtful cases by IEF using MV-N, P and F proteins [3].
  • The replication assay was also used to show that the N, P and L proteins of NiV recognize cis-acting sequences in the genomic termini of Hendra virus (HeV) but not measles virus [4].

High impact information on P


Chemical compound and disease context of P


Biological context of P

  • On the basis of the alignments presented, the estimated amino acid sequence similarity between the N and P genes of PDV and CDV was 84% and 76%, respectively [2].
  • In contrast, all of the mutants retained the ability to form the L-L complex, so different amino acids are involved in the L and P binding sites on L [13].
  • Identification of three lineages of wild measles virus by nucleotide sequence analysis of N, P, M, F, and L genes in Japan [14].
  • These results imply that MV P is a substrate for tyrosine phosphorylation by cellular tyrosine kinase(s) [15].
  • The clinical, virological, and histopathological signs in rabbits infected with the two new recombinant viruses did not differ significantly; therefore, the RPV P gene was considered to be a key determinant of cross-species pathogenicity [16].

Anatomical context of P


Associations of P with chemical compounds

  • These cross-reactivities and type-specific reactions were obtained with the internal viral proteins (M, P and NP) [8].
  • To investigate whether cellular tyrosine kinases can bind and phosphorylate P, a solid phase kinase assay was employed [15].
  • We show that N(TAIL2) has lost the ability to bind to P, thus supporting the hypothesis that the alpha-MoRE may play a role in binding to P. We have further analyzed the alpha-helical propensities of N(TAIL2) and N(TAIL) using circular dichroism in the presence of 2,2,2-trifluoroethanol [22].
  • We speculate that the glutamic acid at position 192 of the measles phosphoprotein is a critical immunogenicity factor and may influence the antigenicity of the naturally processed HLA class II MV-P1 epitope [23].

Analytical, diagnostic and therapeutic context of P


  1. RNA interference with measles virus N, P, and L mRNAs efficiently prevents and with matrix protein mRNA enhances viral transcription. Reuter, T., Weissbrich, B., Schneider-Schaulies, S., Schneider-Schaulies, J. J. Virol. (2006) [Pubmed]
  2. Sequence analysis of the genes encoding the nucleocapsid protein and phosphoprotein (P) of phocid distemper virus, and editing of the P gene transcript. Blixenkrone-Möller, M., Sharma, B., Varsanyi, T.M., Hu, A., Norrby, E., Kövamees, J. J. Gen. Virol. (1992) [Pubmed]
  3. Antibody reactivity to individual structural proteins of measles virus in the CSF of SSPE and MS patients. Pohl-Koppe, A., Kaiser, R., Meulen, V.T., Liebert, U.G. Clinical and diagnostic virology. (1995) [Pubmed]
  4. Nipah virus conforms to the rule of six in a minigenome replication assay. Halpin, K., Bankamp, B., Harcourt, B.H., Bellini, W.J., Rota, P.A. J. Gen. Virol. (2004) [Pubmed]
  5. Measles virus editing provides an additional cysteine-rich protein. Cattaneo, R., Kaelin, K., Baczko, K., Billeter, M.A. Cell (1989) [Pubmed]
  6. Structural basis for the attachment of a paramyxoviral polymerase to its template. Kingston, R.L., Hamel, D.J., Gay, L.S., Dahlquist, F.W., Matthews, B.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Fujinami, R.S., Oldstone, M.B., Wroblewska, Z., Frankel, M.E., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  8. The antigenic relationship between measles, canine distemper and rinderpest viruses studied with monoclonal antibodies. Sheshberadaran, H., Norrby, E., McCullough, K.C., Carpenter, W.C., Orvell, C. J. Gen. Virol. (1986) [Pubmed]
  9. Direct in situ reverse transcriptase polymerase chain reaction for detection of measles virus. Ray, R., Cooper, P.J., Sim, R., Chadwick, N., Earle, P., Dhillon, A.P., Pounder, R.E., Wakefield, A.J. J. Virol. Methods (1996) [Pubmed]
  10. Measles virus phosphoprotein (P) requires the NH2- and COOH-terminal domains for interactions with the nucleoprotein (N) but only the COOH terminus for interactions with itself. Harty, R.N., Palese, P. J. Gen. Virol. (1995) [Pubmed]
  11. Characterization of V protein in measles virus-infected cells. Wardrop, E.A., Briedis, D.J. J. Virol. (1991) [Pubmed]
  12. Expression and properties of the V protein in acute measles virus and subacute sclerosing panencephalitis virus strains. Gombart, A.F., Hirano, A., Wong, T.C. Virus Res. (1992) [Pubmed]
  13. The phosphoprotein (P) and L binding sites reside in the N-terminus of the L subunit of the measles virus RNA polymerase. Cevik, B., Holmes, D.E., Vrotsos, E., Feller, J.A., Smallwood, S., Moyer, S.A. Virology (2004) [Pubmed]
  14. Identification of three lineages of wild measles virus by nucleotide sequence analysis of N, P, M, F, and L genes in Japan. Yamaguchi, S. J. Med. Virol. (1997) [Pubmed]
  15. Tyrosine phosphorylation of measles virus P-phosphoprotein in persistently infected neuroblastoma cells. Ofir, R., Weinstein, Y., Bazarsky, E., Blagerman, S., Wolfson, M., Hunter, T., Rager-Zisman, B. Virus Genes (1996) [Pubmed]
  16. Rinderpest virus phosphoprotein gene is a major determinant of species-specific pathogenicity. Yoneda, M., Miura, R., Barrett, T., Tsukiyama-Kohara, K., Kai, C. J. Virol. (2004) [Pubmed]
  17. Monoclonal antibodies against five structural components of measles virus. II. Characterization of five cell lines persistently infected with measles virus. Sheshberadaran, H., Norrby, E., Rammohan, K.W. Arch. Virol. (1985) [Pubmed]
  18. Antigenic modulation induced by monoclonal antibodies: antibodies to measles virus hemagglutinin alters expression of other viral polypeptides in infected cells. Fujinami, R.S., Norrby, E., Oldstone, M.B. J. Immunol. (1984) [Pubmed]
  19. Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. Ehrengruber, M.U., Ehler, E., Billeter, M.A., Naim, H.Y. J. Virol. (2002) [Pubmed]
  20. Measles virus persistence in an immortalized murine macrophage cell line. Goldman, M.B., Buckthal, D.J., Picciotto, S., O'Bryan, T.A., Goldman, J.N. Virology (1995) [Pubmed]
  21. The assembly of the measles virus nucleoprotein into nucleocapsid-like particles is modulated by the phosphoprotein. Spehner, D., Drillien, R., Howley, P.M. Virology (1997) [Pubmed]
  22. The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner. Bourhis, J.M., Johansson, K., Receveur-Bréchot, V., Oldfield, C.J., Dunker, K.A., Canard, B., Longhi, S. Virus Res. (2004) [Pubmed]
  23. Influence of HLA-DRB1 alleles on lymphoproliferative responses to a naturally processed and presented measles virus phosphoprotein in measles immunized individuals. Ovsyannikova, I.G., Poland, G.A., Easler, N.J., Vierkant, R.A. Hum. Immunol. (2004) [Pubmed]
  24. Antigen mimicry involving measles virus hemagglutinin and human respiratory syncytial virus nucleoprotein. Norrby, E., Sheshberadaran, H., Rafner, B. J. Virol. (1986) [Pubmed]
  25. Evaluation of monoclonal antibody-based capture enzyme immunoassays for detection of specific antibodies to measles virus. Erdman, D.D., Anderson, L.J., Adams, D.R., Stewart, J.A., Markowitz, L.E., Bellini, W.J. J. Clin. Microbiol. (1991) [Pubmed]
  26. Humoral immune response in dogs with old dog encephalitis and chromic distemper meningo-encephalitis. Rima, B.K., Baczko, K., Imagawa, D.T., ter Meulen, V. J. Gen. Virol. (1987) [Pubmed]
  27. Sequence analysis and editing of the phosphoprotein (P) gene of rinderpest virus. Yamanaka, M., Dale, B., Crisp, T., Cordell, B., Grubman, M., Yilma, T. Virology (1992) [Pubmed]
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