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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Vitamin K-dependent protein S is similar to rat androgen-binding protein.

Vitamin K-dependent protein S belongs to the family of clotting factors (e.g. Factors IX and X, and protein C). Unlike the other clotting factors, the C-terminal half (residues 250-634) of protein S is not a serine proteinase. In fact, the function of residues 250-634 of protein S is unknown. By using computer programs designed to detect evolutionary relationships between proteins, we find that this part of protein S is similar to rat androgen-binding protein, a protein produced and secreted by testicular Sertoli cells. The homology between protein S and androgen-binding protein suggests new approaches for elucidating their functions.[1]


  1. Vitamin K-dependent protein S is similar to rat androgen-binding protein. Baker, M.E., French, F.S., Joseph, D.R. Biochem. J. (1987) [Pubmed]
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