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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sertoli Cells

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Disease relevance of Sertoli Cells


Psychiatry related information on Sertoli Cells

  • The critical period of proliferation coincides with the initiation of Sry expression and is essential for the differentiation of Sertoli cells, suggesting that proliferation is a vital component of the initiation of the male pathway by Sry [6].

High impact information on Sertoli Cells

  • In primary Sertoli cells, the orphan nuclear receptor, steroidogenic factor 1 (SF-1), regulates the MIS gene by binding to a conserved upstream regulatory element [7].
  • None of the proteins secreted by Sertoli cells reacted specifically with H-Y antibodies, as determined with immunoprecipitation procedures and immunoabsorbent affinity chromatography, followed by SDS gel electrophoresis [8].
  • This was associated with enhanced tyrosine hydroxylase (TH) immunoreactivity in the striatum in the area around the transplanted Sertoli cells [9].
  • Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats [9].
  • Further analysis of testis showed that CD95 ligand messenger RNA is constitutively expressed by testicular Sertoli cells, and that Sertoli cells from normal mice, but not gld mice, were accepted when transplanted into allogeneic recipients [10].

Chemical compound and disease context of Sertoli Cells


Biological context of Sertoli Cells


Anatomical context of Sertoli Cells


Associations of Sertoli Cells with chemical compounds


Gene context of Sertoli Cells

  • We have studied the expression of ECE by Sertoli cells and used myoid cell cultures and seminiferous tubule explants to monitor the biological activity of the enzymatic reaction product [29].
  • Using Cre/loxP technology, we have generated mice with a ubiquitous knockout of the AR as well as mice with a selective AR knockout in Sertoli cells (SC) only [30].
  • Endogenous expression of Müllerian inhibiting substance in early postnatal rat sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites [31].
  • In mouse Sertoli cells, transcription of the Inha gene encoding the alpha subunit of inhibin, which acts locally as a tumor suppressor, is down-regulated in tumors and in normal cells during aging [32].
  • In Sertoli cells, it colocalizes with the PML and Daxx proteins in punctate nuclear bodies [32].

Analytical, diagnostic and therapeutic context of Sertoli Cells


  1. Transmeiotic differentiation of male germ cells in culture. Rassoulzadegan, M., Paquis-Flucklinger, V., Bertino, B., Sage, J., Jasin, M., Miyagawa, K., van Heyningen, V., Besmer, P., Cuzin, F. Cell (1993) [Pubmed]
  2. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Chang, C., Chen, Y.T., Yeh, S.D., Xu, Q., Wang, R.S., Guillou, F., Lardy, H., Yeh, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. A tumorigenic murine Sertoli cell line that is temperature-sensitive for differentiation. Boekelheide, K., Lee, J.W., Hall, S.J., Rhind, N.R., Zaret, K.S. Am. J. Pathol. (1993) [Pubmed]
  4. HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition. Hirai, K., Sasaki, H., Yamamoto, H., Sakamoto, H., Kubota, Y., Kakizoe, T., Terada, M., Ochiya, T. Exp. Cell Res. (2004) [Pubmed]
  5. Regulation of the phosphoinositide pathway in cultured Sertoli cells from immature rats: effects of follicle-stimulating hormone and fluoride. Quirk, S.M., Reichert, L.E. Endocrinology (1988) [Pubmed]
  6. Cell proliferation is necessary for the determination of male fate in the gonad. Schmahl, J., Capel, B. Dev. Biol. (2003) [Pubmed]
  7. Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade. Shen, W.H., Moore, C.C., Ikeda, Y., Parker, K.L., Ingraham, H.A. Cell (1994) [Pubmed]
  8. The absence of specific interactions of Sertoli-cell-secreted proteins with antibodies directed against H-Y antigen. Gore-Langton, R.E., Tung, P.S., Fritz, I.B. Cell (1983) [Pubmed]
  9. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Sanberg, P.R., Borlongan, C.V., Othberg, A.I., Saporta, S., Freeman, T.B., Cameron, D.F. Nat. Med. (1997) [Pubmed]
  10. A role for CD95 ligand in preventing graft rejection. Bellgrau, D., Gold, D., Selawry, H., Moore, J., Franzusoff, A., Duke, R.C. Nature (1995) [Pubmed]
  11. Inhibitory effects of alkane sulphonates on the function of immature rat Leydig, Sertoli and peritubular cells cultured in vitro. Verhoeven, G., Cailleau, J., Morris, I.D. J. Mol. Endocrinol. (1989) [Pubmed]
  12. Multiple effects of retinoids on the development of Sertoli, germ, and Leydig cells of fetal and neonatal rat testis in culture. Livera, G., Rouiller-Fabre, V., Durand, P., Habert, R. Biol. Reprod. (2000) [Pubmed]
  13. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Dostal, L.A., Chapin, R.E., Stefanski, S.A., Harris, M.W., Schwetz, B.A. Toxicol. Appl. Pharmacol. (1988) [Pubmed]
  14. A morphological, enzyme-cytochemical, and physiological study of the blood-gonad barrier in the hermaphroditic snail Lymnaea stagnalis. de Jong-Brink, M., de With, N.D., Hurkmans, P.J., Bergamin Sassen, M.J. Cell Tissue Res. (1984) [Pubmed]
  15. Effect of thyroid status on the oxidative capacity of Sertoli cells isolated from immature rat testis. Palmero, S., Trucchi, P., Prati, M., Fugassa, E., Lanni, A., Goglia, F. Eur. J. Endocrinol. (1994) [Pubmed]
  16. Cloning and characterization of the urea transporter UT3: localization in rat kidney and testis. Tsukaguchi, H., Shayakul, C., Berger, U.V., Tokui, T., Brown, D., Hediger, M.A. J. Clin. Invest. (1997) [Pubmed]
  17. Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro. Hadley, M.A., Byers, S.W., Suárez-Quian, C.A., Kleinman, H.K., Dym, M. J. Cell Biol. (1985) [Pubmed]
  18. Pituitary follicle-stimulating hormone (FSH) induces CREM gene expression in Sertoli cells: involvement in long-term desensitization of the FSH receptor. Monaco, L., Foulkes, N.S., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Calcium/calmodulin-dependent phosphorylation of vimentin in rat sertoli cells. Spruill, W.A., Zysk, J.R., Tres, L.L., Kierszenbaum, A.L. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  20. Sertoli-Leydig cell communication via an LHRH-like factor. Sharpe, R.M., Fraser, H.M., Cooper, I., Rommerts, F.F. Nature (1981) [Pubmed]
  21. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Parr, B.A., McMahon, A.P. Nature (1998) [Pubmed]
  22. Expression of beta-nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone. Persson, H., Ayer-Le Lievre, C., Söder, O., Villar, M.J., Metsis, M., Olson, L., Ritzen, M., Hökfelt, T. Science (1990) [Pubmed]
  23. Cytochrome c: immunofluorescent localization of the testis-specific form. Goldberg, E., Sberna, D., Wheat, T.E., Urbanski, G.J., Margoliash, E. Science (1977) [Pubmed]
  24. Abnormal sexual development in transgenic mice chronically expressing müllerian inhibiting substance. Behringer, R.R., Cate, R.L., Froelick, G.J., Palmiter, R.D., Brinster, R.L. Nature (1990) [Pubmed]
  25. Follicle-stimulating hormone stimulates estradiol-17beta synthesis in cultured Sertoli cells. Dorrington, J.H., Armstrong, D.T. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  26. Structural changes inducted by follicle-stimulating hormone or dibutyryl cyclic AMP on presumptive Sertoli cells in culture. Tung, P.S., Dorrington, J.H., Fritz, I.B. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  27. Secretion of follicle-stimulating hormone and production of inhibin are reciprocally related. Ying, S.Y., Czvik, J., Becker, A., Ling, N., Ueno, N., Guillemin, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Inflammatory mediators increase surface expression of integrin ligands, adhesion to lymphocytes, and secretion of interleukin 6 in mouse Sertoli cells. Riccioli, A., Filippini, A., De Cesaris, P., Barbacci, E., Stefanini, M., Starace, G., Ziparo, E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction. Tripiciano, A., Peluso, C., Morena, A.R., Palombi, F., Stefanini, M., Ziparo, E., Yanagisawa, M., Filippini, A. J. Cell Biol. (1999) [Pubmed]
  30. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. De Gendt, K., Swinnen, J.V., Saunders, P.T., Schoonjans, L., Dewerchin, M., Devos, A., Tan, K., Atanassova, N., Claessens, F., Lécureuil, C., Heyns, W., Carmeliet, P., Guillou, F., Sharpe, R.M., Verhoeven, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  31. Endogenous expression of Müllerian inhibiting substance in early postnatal rat sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites. Watanabe, K., Clarke, T.R., Lane, A.H., Wang, X., Donahoe, P.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  32. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Lopez, P., Vidal, F., Martin, L., Lopez-Fernandez, L.A., Rual, J.F., Rosen, B.S., Cuzin, F., Rassoulzadegan, M. Mol. Cell. Biol. (2002) [Pubmed]
  33. Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components. Skinner, M.K., Tung, P.S., Fritz, I.B. J. Cell Biol. (1985) [Pubmed]
  34. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. Morita, K., Sasaki, H., Fujimoto, K., Furuse, M., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  35. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. Enomoto, A., Wempe, M.F., Tsuchida, H., Shin, H.J., Cha, S.H., Anzai, N., Goto, A., Sakamoto, A., Niwa, T., Kanai, Y., Anders, M.W., Endou, H. J. Biol. Chem. (2002) [Pubmed]
  36. Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression. Korbutt, G.S., Elliott, J.F., Rajotte, R.V. Diabetes (1997) [Pubmed]
  37. Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1. Bassett, J.H., Rashbass, P., Harding, B., Forbes, S.A., Pannett, A.A., Thakker, R.V. J. Bone Miner. Res. (1999) [Pubmed]
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