Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Schreinemachers, L.M. et al.

Intravesical and intradermal Bacillus Calmette-GuÃ©rin application. A phase I study to the toxicity of a Dutch Bacillus Calmette-GuÃ©rin preparation in patients with superficial bladder cancer.

In 30 patients toxic side effects of Bacillus Calmette-GuÃ©rin (BCG) were evaluated after intradermal and intravesical administration. The BCG preparation (BCG-RIVM) was produced in a homogeneously dispersed culture yielding a relatively high number of culturable particles per milligram dry weight BCG. All patients had a history of recurrent multiple noninvasive superficial transitional cell carcinoma of the bladder, and were previously unsuccessfully treated with intravesical chemotherapy (epodyl and/or adriamycin). BCG-RIVM (1 X 10(9) culturable particles) was instilled in the bladder, in combination with intradermal BCG-RIVM (8 X 10(7) culturable particles) administration once a week for 6 consecutive weeks. BCG was applied intradermally by a multiple-puncture technique. During and after therapy, subjective and objective side effects and toxicity were registered. Hematology and blood chemistry, including hepatic and renal function, was monitored. Only minor toxicity and/or side effects were observed during therapy and for a period of 6 months after treatment. After a period of 7 days no significant amount of BCG bacteria could be detected in the urine of 24 investigated patients.[1]

References

Intravesical and intradermal Bacillus Calmette-Guérin application. A phase I study to the toxicity of a Dutch Bacillus Calmette-Guérin preparation in patients with superficial bladder cancer. Schreinemachers, L.M., van der Meijden, A.P., Wagenaar, J., Steerenberg, P.A., Feitz, W.F., Groothuis, D.G., Tiesjema, R.H., de Jong, W.H., Debruyne, F.M., Ruitenberg, E.J. Eur. Urol. (1988) [Pubmed]

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