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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Administration, Intravesical

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Disease relevance of Administration, Intravesical


High impact information on Administration, Intravesical


Chemical compound and disease context of Administration, Intravesical


Biological context of Administration, Intravesical


Anatomical context of Administration, Intravesical


Associations of Administration, Intravesical with chemical compounds


Gene context of Administration, Intravesical

  • In conclusion, prophylactic intravesical instillations of IFN-alpha-2b in patients with STCC of the bladder have an immunoregulatory effect on the production of IFN-gamma and IL-4 by PBMCs [30].
  • RESULTS: Intravesical injection of ET-1 (0.1 to 10 microM) induced detrusor overactivity, as evidenced by a decrease in intercontraction intervals, in a dose dependent manner [31].
  • In addition, the effect of intravesical administration of resiniferatoxin, an ultra-potent vanilloid receptor agonist, in the receptor expression in the bladder was also studied [32].
  • MATERIALS AND METHODS: Superficial bladder cancer samples before and after four weekly intravesical instillations of 0.7 mg IFN gamma were studied immunohistochemically for proliferative cell nuclear (PCNA) and Ki67 antigens in 25 evaluable patients [33].
  • Interference with the EGF/EGF-R interaction through dietary or pharmacological manipulations of the urine, or via targeting strategies employing intravesical administration of conjugated toxins or isotopes is already being employed in experimental and clinical studies [34].

Analytical, diagnostic and therapeutic context of Administration, Intravesical


  1. Anaphylactic reactions to repeated intravesical instillation with cisplatin. Denis, L. Lancet (1983) [Pubmed]
  2. Enhancement of transformation in vitro of a nontumorigenic rat urothelial cell line by interleukin 6. Okamoto, M., Kawamata, H., Kawai, K., Oyasu, R. Cancer Res. (1995) [Pubmed]
  3. Granulomatous hepatitis caused by Bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation. Leebeek, F.W., Ouwendijk, R.J., Kolk, A.H., Dees, A., Meek, J.C., Nienhuis, J.E., Dingemans-Dumas, A.M. Gut (1996) [Pubmed]
  4. Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein. Benedict, W.F., Tao, Z., Kim, C.S., Zhang, X., Zhou, J.H., Adam, L., McConkey, D.J., Papageorgiou, A., Munsell, M., Philopena, J., Engler, H., Demers, W., Maneval, D.C., Dinney, C.P., Connor, R.J. Mol. Ther. (2004) [Pubmed]
  5. Prostaglandin E1 bladder instillations to control severe hemorrhagic cystitis. Trigg, M.E., O'Reilly, J., Rumelhart, S., Morgan, D., Holida, M., de Alarcon, P. J. Urol. (1990) [Pubmed]
  6. Regional chemotherapy for bladder neoplasms using continuous intravesical infusion of doxorubicin: impact of concomitant administration of dimethyl sulfoxide on drug absorption and antitumor activity. See, W.A., Xia, Q. J. Natl. Cancer Inst. (1992) [Pubmed]
  7. Behavioral profiling of human transitional cell carcinoma ex vivo. Estrada, C.R., Salanga, M., Bielenberg, D.R., Harrell, W.B., Zurakowski, D., Zhu, X., Palmer, M.R., Freeman, M.R., Adam, R.M. Cancer Res. (2006) [Pubmed]
  8. Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation. Kuball, J., Wen, S.F., Leissner, J., Atkins, D., Meinhardt, P., Quijano, E., Engler, H., Hutchins, B., Maneval, D.C., Grace, M.J., Fritz, M.A., Störkel, S., Thüroff, J.W., Huber, C., Schuler, M. J. Clin. Oncol. (2002) [Pubmed]
  9. Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression. Kaempfer, R., Gerez, L., Farbstein, H., Madar, L., Hirschman, O., Nussinovich, R., Shapiro, A. J. Clin. Oncol. (1996) [Pubmed]
  10. Early induction of mouse urinary bladder ornithine decarboxylase activity by rodent vesical carcinogens. Matsushima, M., Bryan, G.T. Cancer Res. (1980) [Pubmed]
  11. Skin abscess after intravesical instillation of bacillus Calmette-Guerin for prophylactic treatment of transitional cell carcinoma. Mangiarotti, B., Trinchieri, A., Marconato, R., Pisani, E. J. Urol. (2002) [Pubmed]
  12. Bladder contracture following intravesical doxorubicin therapy: case report and a review of the literature. Dmochowski, R., Rudy, D.C. J. Urol. (1990) [Pubmed]
  13. A randomized controlled trial of short-term versus long-term prophylactic intravesical instillation chemotherapy for recurrence after transurethral resection of Ta/T1 transitional cell carcinoma of the bladder. Koga, H., Kuroiwa, K., Yamaguchi, A., Osada, Y., Tsuneyoshi, M., Naito, S. J. Urol. (2004) [Pubmed]
  14. Interstitial cystitis: bladder training with intravesical oxybutynin. Barbalias, G.A., Liatsikos, E.N., Athanasopoulos, A., Nikiforidis, G. J. Urol. (2000) [Pubmed]
  15. Whole bladder photodynamic therapy for orthotopic superficial bladder cancer in rats: a study of intravenous and intravesical administration of photosensitizers. Xiao, Z., Brown, K., Tulip, J., Moore, R.B. J. Urol. (2003) [Pubmed]
  16. Nonviral cytokine gene therapy on an orthotopic bladder cancer model. Wu, Q., Mahendran, R., Esuvaranathan, K. Clin. Cancer Res. (2003) [Pubmed]
  17. The pharmacokinetics of intravesical and oral oxybutynin chloride. Massad, C.A., Kogan, B.A., Trigo-Rocha, F.E. J. Urol. (1992) [Pubmed]
  18. Urodynamic effects of intravesical instillation of terodiline in healthy volunteers and in patients with detrusor hyperactivity. Ekström, B., Andersson, K.E., Mattiasson, A. J. Urol. (1992) [Pubmed]
  19. New techniques for the administration of topical adjuvant therapy after endoscopic ablation of upper urinary tract transitional cell carcinoma. Patel, A., Fuchs, G.J. J. Urol. (1998) [Pubmed]
  20. Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: A pilot study. Walter, P., Grosse, J., Bihr, A.M., Kramer, G., Schulz, H.U., Schwantes, U., Stöhrer, M. Neurourology and urodynamics. (1999) [Pubmed]
  21. Urodynamic effects of intravesical instillation of lidocaine in patients with overactive detrusor. Yokoyama, O., Ishiura, Y., Nakamura, Y., Kunimi, K., Mita, E., Namiki, M. J. Urol. (1997) [Pubmed]
  22. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans. Maggi, C.A., Barbanti, G., Santicioli, P., Beneforti, P., Misuri, D., Meli, A., Turini, D. J. Urol. (1989) [Pubmed]
  23. Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia. Sasaki, K., Chancellor, M.B., Phelan, M.W., Yokoyama, T., Fraser, M.O., Seki, S., Kubo, K., Kumon, H., Groat, W.C., Yoshimura, N. J. Urol. (2002) [Pubmed]
  24. Intravesical electrical stimulation--an experimental analysis of the mechanism of action. Ebner, A., Jiang, C., Lindström, S. J. Urol. (1992) [Pubmed]
  25. Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. Oki, T., Kimura, R., Saito, M., Miyagawa, I., Yamada, S. J. Urol. (2004) [Pubmed]
  26. Ion exchange tumor targeting: a new approach. Holmberg, A.R., Wilchek, M., Márquez, M., Westlin, J.E., Du, J., Nilsson, S. Clin. Cancer Res. (1999) [Pubmed]
  27. Clinical pharmacokinetics of epirubicin. Robert, J. Clinical pharmacokinetics. (1994) [Pubmed]
  28. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. Beckel, J.M., Kanai, A., Lee, S.J., de Groat, W.C., Birder, L.A. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  29. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. Chopra, B., Barrick, S.R., Meyers, S., Beckel, J.M., Zeidel, M.L., Ford, A.P., de Groat, W.C., Birder, L.A. J. Physiol. (Lond.) (2005) [Pubmed]
  30. Prophylactic intracavitary treatment with interferon alpha increases interferon gamma production by peripheral blood mononuclear cells in patients with superficial transitional cell carcinoma of the bladder. Moltó, L., Carballido, J., Manzano, L., Reyes, E., Olivier, C., Alvarez-Mon, M. Br. J. Cancer (1997) [Pubmed]
  31. Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats. Ogawa, T., Kamo, I., Pflug, B.R., Nelson, J.B., Seki, S., Igawa, Y., Nishizawa, O., de Groat, W.C., Chancellor, M.B., Yoshimura, N. J. Urol. (2004) [Pubmed]
  32. Vanilloid receptor 1 expression in the rat urinary tract. Avelino, A., Cruz, C., Nagy, I., Cruz, F. Neuroscience (2002) [Pubmed]
  33. Antiproliferative activity of interferon gamma in superficial bladder cancer. Stavropoulos, N.E., Ioachim, E., Pappa, L., Hastazeris, K., Agnantis, N.J. Anticancer Res. (1999) [Pubmed]
  34. Epidermal growth factor and its receptor: markers of--and targets for--chemoprevention of bladder cancer. Messing, E.M., Reznikoff, C.A. J. Cell. Biochem. Suppl. (1992) [Pubmed]
  35. Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer. Le Visage, C., Rioux-Leclercq, N., Haller, M., Breton, P., Malavaud, B., Leong, K. J. Urol. (2004) [Pubmed]
  36. Photodynamic therapy on rat urinary bladder with intravesical instillation of 5-aminolevulinic acid: light diffusion and histological changes. Chang, S.C., MacRobert, A.J., Bown, S.G. J. Urol. (1996) [Pubmed]
  37. The effects of intravesical pretreatment with pentosan polysulfate on the bacillus Calmette-Guérin induced immune reaction of the guinea pig. De Reijke, T.M., De Boer, L.C., Steerenberg, P.A., Vos, P.C., Kurth, K.H., Schamhart, D.H. J. Urol. (1994) [Pubmed]
  38. Inhibition of implantation of murine bladder tumor by thiotepa in cauterized bladder. Pan, J.S., Slocum, H.K., Rustum, Y.M., Greco, W.R., Gaeta, J.F., Huben, R.P. J. Urol. (1989) [Pubmed]
  39. The ultrastructure of transitional cell carcinomas of the human urinary bladder treated with ethoglucid or mitomycin. Stewart, R.J., Lawson, A.H., Weaver, J.P. J. Urol. (1988) [Pubmed]
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