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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sodium potassium ATPase activity in human rectal mucosa with and without renal insufficiency.

Studies in rats have shown that fecal potassium excretion and colonic mucosa Na-K-ATPase activity are elevated during dietary potassium loading and in chronic renal insufficiency. We studied Na-K-ATPase activity in human rectal mucosa in normal subjects as well as in patients with chronic renal insufficiency (creatinine clearance 2 to 72 mL/min). In normals, Na-K-ATPase activity was 4.34 +/- 0.83 mumol P/mg protein. After 2 weeks on a potassium intake of 300 mmol/d the mean activity did not differ significantly from the control value (2.49 +/- 1.30). In none of the patients with renal failure was Na-K-ATPase activity beyond the range found in the normal subjects, irrespective of serum potassium; the mean activity was 3.50 +/- 0.85. Like others, however, we found a two-fold increase in Na-K-ATPase activity in potassium loaded rats. Possible explanations for these differences are discussed.[1]


  1. Sodium potassium ATPase activity in human rectal mucosa with and without renal insufficiency. Hené, R.J., Boer, P., Koomans, H.A., Dorhout Mees, E.J. Am. J. Kidney Dis. (1985) [Pubmed]
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