Sequence homologies in the control regions of c-myc, c-fos, HTLV and the interleukin-2 receptor.
Homologies in the control regions of 2 cellular oncogenes have been identified in this study. Both oncogenes (c-myc and c-fos) are known to be transiently induced by mitogens. We suggest that transcriptional activators bind to these putative control sequences, thus de-regulating gene expression in a coordinated and cell-cycle specific manner. In addition, we report on homologous sequences in the control regions of the human T-cell leukemia viruses types I and II, and in the flanking region of the gene coding for the interleukin-2 receptor. These, and other experimental data, lead to the formation of a model in terms of which the unlimited proliferation of cells infected with HTLV-I and -II may be explained. The differing biological effects of HTLV-I, -II and -III are also examined and discussed at a molecular level.[1]References
- Sequence homologies in the control regions of c-myc, c-fos, HTLV and the interleukin-2 receptor. Renan, M.J. Cancer Lett. (1985) [Pubmed]
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