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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes.

A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes. Variants at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can therefore be described as 'pseudoautosomal'. Another probe from the same cosmid detects a sequence repeated 15-20 times per haploid genome. These repeats also appear pseudoautosomal and map exclusively to the short-arm terminal region of each sex chromosome.[1]


  1. Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes. Simmler, M.C., Rouyer, F., Vergnaud, G., Nyström-Lahti, M., Ngo, K.Y., de la Chapelle, A., Weissenbach, J. Nature (1985) [Pubmed]
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