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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus.

The expression of endogenous retroviral genes in mammals may be etiologically related to genetic diseases including cancer. Recently, A-type human endogenous retroviral genomes have been cloned using the reverse transcriptase (pol) genes of rodent intracisternal A-particles (IAP). In this report, RNA from human colon adenocarcinoma and surrounding mucosa was hybridized to mouse IAP pol and gag genes to examine the expression of human endogenous A-type retroviruses. Abundant, heterogeneous size, polyadenylated transcripts homologous to the mouse IAP pol gene were detected in both tissues. Transcripts homologous to the mouse IAP gag region were not found.[1]

References

  1. mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus. Moshier, J.A., Luk, G.D., Huang, R.C. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
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