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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Naftifine cream in the treatment of cutaneous candidiasis.

Naftifine, a member of a new class of synthetic antifungal drugs, the allylamines, was evaluated for the treatment of cutaneous candidiasis. In a double-blind, parallel-group clinical trial, sixty patients with cutaneous candidiasis were randomly assigned to receive either naftifine cream 1 percent or its vehicle twice a day for three weeks. Two weeks after the end of therapy, 77 percent of the naftifine-treated patients were mycologically cured (negative results on potassium hydroxide preparations and culture) and had no clinically apparent disease, compared with 3 percent of the patients treated with vehicle (p less than 0.001). Side effects reported with naftifine cream were few and minor.[1]


  1. Naftifine cream in the treatment of cutaneous candidiasis. Zaias, N., Astorga, E., Cordero, C.N., Day, R.M., de Espinoza, Z.D., DeGryse, R., Rojas, R.F., Sefton, J. Cutis; cutaneous medicine for the practitioner. (1988) [Pubmed]
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