Disease relevance of Naftifine

• Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses [1].
• Its formulations are at least as effective as miconazole 2% cream and naftifine 1% gel in tinea pedis, and more effective than clotrimazole 1% cream, bifonazole 1% cream and oxiconazole 1% lotion [2].
• Allergic contact dermatitis to naftifine [3].
• A double-blind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses [4].
• Naftifine cream in the treatment of cutaneous candidiasis [5].

High impact information on Naftifine

• It also has greater activity against T. rubrum, M. gypseum and Epidermophyton floccosum when compared with naftifine, tolnaftate and clotrimazole; comparisons with bifonazole against these strains were not available [6].
• In the presence of terbinafine or naftifine, chemotaxis of PMNs was not impaired [7].
• Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes [7].
• This evidence suggests that the antimycotic action of Naftifine results from interaction of the agent with fungal lipid metabolism and possibly from alterations of the cell wall structure [8].
• These results suggest that sertaconazole is more active against Candida spp than other topical agents such as bifonazole and naftifine [9].

Chemical compound and disease context of Naftifine

• Allergic contact dermatitis from naftifine in a child without cross-reaction to terbinafine [10].
• Ten patients with culture-proven distal subungual onychomycosis were treated twice daily for six months with naftifine hydrochloride 1 percent gel [11].
• On a concentration basis amorolfine is more effective in trichophytosis than naftifine and all azoles tested [12].
• The use of naftifine (Exoderil) cream in the treatment of dermatophytosis [13].

Biological context of Naftifine

• Major routes of naftifine biotransformation in laboratory animals and man [14].
• The same pathways of naftifine biotransformation were observed in all species investigated, i.e. in man, rat, dog, rabbit and guinea pig, the last two species most closely resembling to man with respect to overall kinetics and urinary metabolite pattern [14].

Associations of Naftifine with other chemical compounds

• The most frequently isolated pathogens were dermatophytes, mainly Trichophyton rubrum; however, Candida albicans was present in 33.3% of patients in the fenticonazole group and in 20.8% of those treated with naftifine [4].
• The antifungal activity of SF 86-327 was compared in vitro with those of naftifine, ketoconazole, and itraconazole (R 51,211, Janssen Pharmaceutica) by agar dilution [15].
• The antidermatophytic activity of the two main compounds, naftifine and terbinafine were compared in vitro with those of ketoconazole and itraconazole by agar dilution [16].
• Following penetration in vitro, naftifine gel and cream were significantly more active against T. rubrum than econazole nitrate cream 1 percent [17].
• The isolates of the genus Absidia and Syncephalastrum were well sensitive to all antimycotics with the exception of 5-fluorocytosine and naftifine [18].

Analytical, diagnostic and therapeutic context of Naftifine

• The morphological changes in the hyphae of Trichophyton mentagrophytes treated with Naftifine (0.01-0.5 micrograms/ml) were studied by light and electron microscopy [8].
• Low voltage scanning electron microscopy study of naftifine activity on Microsporum canis [19].
• The Microsporum canis morphology alterations induced by naftifine at a concentration of 0.9 microgram ml-1 (10 times the minimum inhibitory concentration (MIC) for 7 days were studied in LVSEM [19].
• A cytological study with transmission electron microscopy (TEM) of filaments altered by naftifine permitted us to observe the disorganization of cell wall fibrillar structure, an excessive plasma membrane undulation and an intracytoplasmic accumulation of large vesicles with probably lipidic contents [19].

References