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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome.

A double-blind randomized crossover study of 7.5 mg bromocriptine at bedtime versus placebo was conducted in 30-day phases (with a 2-week washout period between phases) in 6 patients with idiopathic restless legs syndrome. Five patients experienced partial subjective improvement in restlessness and paresthesias on bromocriptine as opposed to placebo and expressed a desire to continue on the medication. On bromocriptine, the patients showed polysomnographically a mean decrease of 43% from control and a mean decrease of 57% from placebo in the number of periodic movements of sleep per hour of sleep (p less than 0.025). Two of 3 patients with abnormally decreased total sleep time and sleep efficiency showed an improvement in these measures on therapy. The dopamine agonist bromocriptine may be a useful therapy in some patients with restless legs syndrome.[1]

References

  1. A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. Walters, A.S., Hening, W.A., Kavey, N., Chokroverty, S., Gidro-Frank, S. Ann. Neurol. (1988) [Pubmed]
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