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Disease relevance of Paresthesia


Psychiatry related information on Paresthesia

  • BACKGROUND: GSS, associated with a missense mutation at codon 102 of the prion protein (PrP) gene (GSS102), is a hereditary disorder that presents with progressive ataxia and dementia, and is characterized by the loss of deep tendon reflexes and painful dysesthesias of the legs in its early stage [6].
  • Step-by-step adjustment of pulse output parameters was performed at the electrode configuration at which paresthesias occurred ("sensory threshold"), covered the anginal area ("adjusted setting"), or provoked pain ("motor threshold") [7].

High impact information on Paresthesia

  • Adverse events included nausea, circumoral paresthesia, elevated hepatic aminotransferase levels, and elevated triglyceride levels [8].
  • Astemizole-induced paresthesia [9].
  • Several traditional findings of CTS have little or no diagnostic value, including nocturnal paresthesias; Phalen and Tinel signs; thenar atrophy; and 2-point, vibratory, and monofilament sensory testing [10].
  • Adverse events significantly associated with tacrolimus, including headache, increased serum creatinine level, insomnia, leg cramps, paresthesias, and tremor, were managed with dose reduction [11].
  • Paresthesias and mefloquine prophylaxis [12].

Chemical compound and disease context of Paresthesia


Biological context of Paresthesia


Anatomical context of Paresthesia


Gene context of Paresthesia

  • Paresthesias, often described as electric shocks (Lhermitte sign), were common in GDNF-treated subjects, were not dose related, and resolved on discontinuation of GDNF [27].
  • After IFN-beta treatment, HCV RNA was cleared from serum without severe adverse effects, including paresthesias [28].
  • Because severe paresthesias occurred with initial daily administration of 5 million units (MU) of lymphoblastoid IFN-alpha, the dose was reduced to 3 to 6 MU of IFN-alpha2b three times a week [28].
  • PRTG was associated wtih an 8% risk of complications, which included anesthesia dolorosa, corneal anesthesia with keratitis, and significant facial paresthesias [29].
  • In group S (single injection, n = 53) 80 mL MEPE 1% were injected into the neurovascular sheath, transarterially or after eliciting paresthesia [30].

Analytical, diagnostic and therapeutic context of Paresthesia


  1. Acute fluoride poisoning from a public water system. Gessner, B.D., Beller, M., Middaugh, J.P., Whitford, G.M. N. Engl. J. Med. (1994) [Pubmed]
  2. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. Silver, R.M., Heyes, M.P., Maize, J.C., Quearry, B., Vionnet-Fuasset, M., Sternberg, E.M. N. Engl. J. Med. (1990) [Pubmed]
  3. Physiological effects of 4-aminopyridine on demyelinated mammalian motor and sensory fibers. Bowe, C.M., Kocsis, J.D., Targ, E.F., Waxman, S.G. Ann. Neurol. (1987) [Pubmed]
  4. The effect of 4-aminopyridine on clinical signs in multiple sclerosis: a randomized, placebo-controlled, double-blind, cross-over study. van Diemen, H.A., Polman, C.H., van Dongen, T.M., van Loenen, A.C., Nauta, J.J., Taphoorn, M.J., van Walbeek, H.K., Koetsier, J.C. Ann. Neurol. (1992) [Pubmed]
  5. Effects of acetazolamide on myotonia. Griggs, R.C., Moxley, R.T., Riggs, J.E., Engel, W.K. Ann. Neurol. (1978) [Pubmed]
  6. Involvement of the spinal posterior horn in Gerstmann-Sträussler-Scheinker disease (PrP P102L). Yamada, M., Tomimitsu, H., Yokota, T., Tomi, H., Sunohara, N., Mukoyama, M., Itoh, Y., Suematsu, N., Otomo, E., Okeda, R., Matsushita, M., Mizusawa, H. Neurology (1999) [Pubmed]
  7. Stimulation characteristics, complications, and efficacy of spinal cord stimulation systems in patients with refractory angina: a prospective feasibility study. de Jongste, M.J., Nagelkerke, D., Hooyschuur, C.M., Journée, H.L., Meyler, P.W., Staal, M.J., de Jonge, P., Lie, K.I. Pacing and clinical electrophysiology : PACE. (1994) [Pubmed]
  8. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group. Danner, S.A., Carr, A., Leonard, J.M., Lehman, L.M., Gudiol, F., Gonzales, J., Raventos, A., Rubio, R., Bouza, E., Pintado, V. N. Engl. J. Med. (1995) [Pubmed]
  9. Astemizole-induced paresthesia. Kaufman, H.S., Chang, P., Chang, G. N. Engl. J. Med. (1990) [Pubmed]
  10. The rational clinical examination. Does this patient have carpal tunnel syndrome? D'Arcy, C.A., McGee, S. JAMA (2000) [Pubmed]
  11. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Sandborn, W.J., Present, D.H., Isaacs, K.L., Wolf, D.C., Greenberg, E., Hanauer, S.B., Feagan, B.G., Mayer, L., Johnson, T., Galanko, J., Martin, C., Sandler, R.S. Gastroenterology (2003) [Pubmed]
  12. Paresthesias and mefloquine prophylaxis. Olson, P.E., Kennedy, C.A., Morte, P.D. Ann. Intern. Med. (1992) [Pubmed]
  13. The neurotoxicity of antibacterial agents. Snavely, S.R., Hodges, G.R. Ann. Intern. Med. (1984) [Pubmed]
  14. Formication and azathioprine therapy. Brandt, L.J. Ann. Intern. Med. (1977) [Pubmed]
  15. Clinical features of types A and B food-borne botulism. Hughes, J.M., Blumenthal, J.R., Merson, M.H., Lombard, G.L., Dowell, V.R., Gangarosa, E.J. Ann. Intern. Med. (1981) [Pubmed]
  16. Amprenavir in combination with lamivudine and zidovudine versus lamivudine and zidovudine alone in HIV-1-infected antiretroviral-naive adults. Amprenavir PROAB3001 International Study Team. Goodgame, J.C., Pottage, J.C., Jablonowski, H., Hardy, W.D., Stein, A., Fischl, M., Morrow, P., Feinberg, J., Brothers, C.H., Vafidis, I., Nacci, P., Yeo, J., Pedneault, L. Antivir. Ther. (Lond.) (2000) [Pubmed]
  17. Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. Florkowski, C.M., Rowe, B.R., Nightingale, S., Harvey, T.C., Barnett, A.H. Diabetes (1991) [Pubmed]
  18. Neurotoxicological effects and the mode of action of pyrethroid insecticides. Vijverberg, H.P., van den Bercken, J. Crit. Rev. Toxicol. (1990) [Pubmed]
  19. Diuretic effects, pharmacokinetics, and safety of a new centrally acting kappa-opioid agonist (CI-977) in humans. Reece, P.A., Sedman, A.J., Rose, S., Wright, D.S., Dawkins, R., Rajagopalan, R. Journal of clinical pharmacology. (1994) [Pubmed]
  20. Comparison of aerosolized glycopyrrolate and metaproterenol in acute asthma. Gilman, M.J., Meyer, L., Carter, J., Slovis, C. Chest (1990) [Pubmed]
  21. Methyl bromide optic atrophy. Chavez, C.T., Hepler, R.S., Straatsma, B.R. Am. J. Ophthalmol. (1985) [Pubmed]
  22. Fosphenytoin. Luer, M.S. Neurol. Res. (1998) [Pubmed]
  23. Clinical spectrum and prevalence of neurologic events provoked by tilt table testing. Passman, R., Horvath, G., Thomas, J., Kruse, J., Shah, A., Goldberger, J., Kadish, A. Arch. Intern. Med. (2003) [Pubmed]
  24. Epileptogenic agents applied to trigeminal ganglia: absence of neuronal hyperexcitability. Burchiel, K.J., Wyler, A.R., Harris, A.B. Epilepsia (1978) [Pubmed]
  25. Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. Eide, P.K., Stubhaug, A., Stenehjem, A.E. Neurosurgery (1995) [Pubmed]
  26. Traumatic dysesthesia of the trigeminal nerve. Canavan, D., Graff-Radford, S.B., Gratt, B.M. Journal of orofacial pain. (1994) [Pubmed]
  27. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Nutt, J.G., Burchiel, K.J., Comella, C.L., Jankovic, J., Lang, A.E., Laws, E.R., Lozano, A.M., Penn, R.D., Simpson, R.K., Stacy, M., Wooten, G.F. Neurology (2003) [Pubmed]
  28. Complete response to twice-a-day interferon-beta with standard interferon-alpha therapy in acute hepatitis C after a needle-stick. Oketani, M., Higashi, T., Yamasaki, N., Shinmyozu, K., Osame, M., Arima, T. J. Clin. Gastroenterol. (1999) [Pubmed]
  29. Comparison of percutaneous radiofrequency gangliolysis and microvascular decompression for the surgical management of tic douloureux. Burchiel, K.J., Steege, T.D., Howe, J.F., Loeser, J.D. Neurosurgery (1981) [Pubmed]
  30. Low dose axillary block by targeted injections of the terminal nerves. Koscielniak-Nielsen, Z.J., Rotbøll Nielsen, P., Sørensen, T., Stenør, M. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1999) [Pubmed]
  31. Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients. Capdevila, X., Pirat, P., Bringuier, S., Gaertner, E., Singelyn, F., Bernard, N., Choquet, O., Bouaziz, H., Bonnet, F. Anesthesiology (2005) [Pubmed]
  32. Effectiveness of a piroxicam fast dissolving formulation sublingually administered in the symptomatic treatment of migraine without aura. Nappi, G., Micieli, G., Tassorelli, C., Viotti, E., Altavilla, T. Headache. (1993) [Pubmed]
  33. Evaluation of a new protocol for peripheral blood stem cell collection with the Fresenius AS 104 cell separator. Menichella, G., Lai, M., Pierelli, L., Serafini, R., Vittori, M., Ciarli, M., Foddai, M.L., Puglia, G., Mitschulat, H., Scambia, G., Leone, G., Bizzi, B. Journal of clinical apheresis. (1997) [Pubmed]
  34. Long-term outcome of spinal cord electrical stimulation in patients with refractory chest pain. Bagger, J.P., Jensen, B.S., Johannsen, G. Clinical cardiology. (1998) [Pubmed]
  35. Repeated episodes of transient radiating back and leg pain following spinal anesthesia with 1.5% mepivacaine and 2% lidocaine. Liguori, G.A., Zayas, V.M. Regional anesthesia and pain medicine. (1998) [Pubmed]
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