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MeSH Review

Restless Legs Syndrome

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Disease relevance of Restless Legs Syndrome


Psychiatry related information on Restless Legs Syndrome


High impact information on Restless Legs Syndrome


Chemical compound and disease context of Restless Legs Syndrome


Biological context of Restless Legs Syndrome


Anatomical context of Restless Legs Syndrome

  • Cerebrospinal fluid (CSF) and blood obtained from 22 untreated or scarcely treated patients with moderate to severe restless legs syndrome (RLS; mean age, 58.6 +/- 13 years) and 11 control subjects (mean age, 56.6 +/- 12.9 years) were investigated for biogenic amines between 6:00 and 8:00 PM [23].
  • The aim of this study is evaluating iron, ferritin, and transferrin in both serum and CSF in patients of restless legs syndrome (RLS), based on the hypothesis that iron deficiency in the central nervous system (CNS) causes the symptoms as a result of the dysfunction of dopaminergic systems [24].

Gene context of Restless Legs Syndrome


Analytical, diagnostic and therapeutic context of Restless Legs Syndrome


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  3. Transverse myelitis associated with restless legs syndrome and periodic movements of sleep responsive to an oral dopaminergic agent but not to intrathecal baclofen. Brown, L.K., Heffner, J.E., Obbens, E.A. Sleep. (2000) [Pubmed]
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  7. Sleepiness and sleep disorders in shift workers: a study on a group of italian police officers. Garbarino, S., De Carli, F., Nobili, L., Mascialino, B., Squarcia, S., Penco, M.A., Beelke, M., Ferrilla, F. Sleep. (2002) [Pubmed]
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  9. Genetic association of Huntington's disease and restless legs syndrome? A family report. Evers, S., Stögbauer, F. Mov. Disord. (2003) [Pubmed]
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  11. Folate deficiency and restless-legs syndrome in pregnancy. Botez, M.I., Lambert, B. N. Engl. J. Med. (1977) [Pubmed]
  12. Levodopa in restless legs. von Scheele, C. Lancet (1986) [Pubmed]
  13. A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. Walters, A.S., Hening, W.A., Kavey, N., Chokroverty, S., Gidro-Frank, S. Ann. Neurol. (1988) [Pubmed]
  14. Successful treatment of restless legs with clonazepam. Boghen, D. Ann. Neurol. (1980) [Pubmed]
  15. Selective serotonin receptor uptake inhibitors can reduce restless legs symptoms. Dimmitt, S.B., Riley, G.J. Arch. Intern. Med. (2000) [Pubmed]
  16. L-Tryptophan in the treatment of restless legs syndrome. Sandyk, R. The American journal of psychiatry. (1986) [Pubmed]
  17. Propranolol in the treatment of restless legs syndrome induced by imipramine withdrawal. Ginsberg, H.N. The American journal of psychiatry. (1986) [Pubmed]
  18. Encouraging initial response of restless legs syndrome to pramipexole. Becker, P.M., Ondo, W., Sharon, D. Neurology (1998) [Pubmed]
  19. Treatment of idiopathic restless legs syndrome (RLS) with gabapentin. Happe, S., Klösch, G., Saletu, B., Zeitlhofer, J. Neurology (2001) [Pubmed]
  20. Restless legs syndrome induced by lithium. Terao, T., Terao, M., Yoshimura, R., Abe, K. Biol. Psychiatry (1991) [Pubmed]
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  22. Reflex studies and MRI in the restless legs syndrome. Bucher, S.F., Trenkwalder, C., Oertel, W.H. Acta neurologica Scandinavica. (1996) [Pubmed]
  23. Normal dopaminergic and serotonergic metabolites in cerebrospinal fluid and blood of restless legs syndrome patients. Stiasny-Kolster, K., Möller, J.C., Zschocke, J., Bandmann, O., Cassel, W., Oertel, W.H., Hoffmann, G.F. Mov. Disord. (2004) [Pubmed]
  24. CSF iron, ferritin and transferrin levels in restless legs syndrome. Mizuno, S., Mihara, T., Miyaoka, T., Inagaki, T., Horiguchi, J. Journal of sleep research. (2005) [Pubmed]
  25. Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. Desautels, A., Turecki, G., Montplaisir, J., Brisebois, K., Sequeira, A., Adam, B., Rouleau, G.A. Neurology (2002) [Pubmed]
  26. Mutational analysis of neurotensin in familial restless legs syndrome. Desautels, A., Turecki, G., Xiong, L., Rochefort, D., Montplaisir, J., Rouleau, G.A. Mov. Disord. (2004) [Pubmed]
  27. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Connor, J.R., Wang, X.S., Patton, S.M., Menzies, S.L., Troncoso, J.C., Earley, C.J., Allen, R.P. Neurology (2004) [Pubmed]
  28. Iron metabolism and the risk of restless legs syndrome in an elderly general population--the MEMO-Study. Berger, K., von Eckardstein, A., Trenkwalder, C., Rothdach, A., Junker, R., Weiland, S.K. J. Neurol. (2002) [Pubmed]
  29. Restless legs syndrome in spinocerebellar ataxia types 1, 2, and 3. Abele, M., Bürk, K., Laccone, F., Dichgans, J., Klockgether, T. J. Neurol. (2001) [Pubmed]
  30. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Garcia-Borreguero, D., Larrosa, O., de la Llave, Y., Verger, K., Masramon, X., Hernandez, G. Neurology (2002) [Pubmed]
  31. Normal IPT and IBZM SPECT in drug naive and levodopa-treated idiopathic restless legs syndrome. Tribl, G.G., Asenbaum, S., Klösch, G., Mayer, K., Bonelli, R.M., Auff, E., Zeitlhofer, J., Happe, S. Neurology (2002) [Pubmed]
  32. Pramipexole in Restless Legs syndrome. Evaluation by suggested immobilization test. Manconi, M., Casetta, I., Govoni, V., Cesnik, E., Ferini-Strambi, L., Granieri, E. J. Neurol. (2003) [Pubmed]
  33. Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia. Okun, M.S., Fernandez, H.H., Foote, K.D. Mov. Disord. (2005) [Pubmed]
  34. Positron emission tomographic studies in restless legs syndrome. Trenkwalder, C., Walters, A.S., Hening, W.A., Chokroverty, S., Antonini, A., Dhawan, V., Eidelberg, D. Mov. Disord. (1999) [Pubmed]
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