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Meltzer, E.O. et al.

Efficacy of azelastine in perennial allergic rhinitis: clinical and rhinomanometric evaluation.

Azelastine is a chemically novel medication that has been demonstrated to be clinically effective for asthma and seasonal allergic rhinitis. In a 10-week, multicenter, double-blind, placebo-controlled, crossover study, the efficacy and safety of azelastine, 1 mg and 2 mg twice daily, were evaluated in 192 patients with symptoms of perennial allergic rhinitis. Patients maintained daily symptom and adverse-experience diaries and were evaluated every 2 weeks by the investigators. Pseudoephedrine, 30 mg, was provided as backup medication. Amelioration of most individual symptoms and a decrease in the total symptom scores were observed with both dosages of azelastine; greater improvement with 2 mg twice daily than with 1 mg twice daily, was observed. Nasal congestion, as a symptom and as reflected by rhinomanometric assessment, was the least improved parameter. Backup decongestant medication decreased during treatment with azelastine and increased during the placebo regimen. There were no major adverse effects.[1]

References

Efficacy of azelastine in perennial allergic rhinitis: clinical and rhinomanometric evaluation. Meltzer, E.O., Storms, W.W., Pierson, W.E., Cummins, L.H., Orgel, H.A., Perhach, J.L., Hemsworth, G.R. J. Allergy Clin. Immunol. (1988) [Pubmed]

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