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Chemical Compound Review

Ephedrine     2-methylamino-1-phenyl- propan-1-ol

Synonyms: racephedrine, Ephedrine dl-, Ephedrine,(+), Ephedrine,(-), SureCN4369, ...
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Disease relevance of PSEUDOEPHEDRINE


Psychiatry related information on PSEUDOEPHEDRINE


High impact information on PSEUDOEPHEDRINE


Chemical compound and disease context of PSEUDOEPHEDRINE


Biological context of PSEUDOEPHEDRINE


Anatomical context of PSEUDOEPHEDRINE


Associations of PSEUDOEPHEDRINE with other chemical compounds

  • On the other hand, intravenous norepinephrine and oral ephedrine blunted the CSM-induced drop in systolic pressure (CSM with norepinephrine, -19 +/- 12 mm Hg; CSM with ephedrine, -21 +/- 11 mm Hg; both p less than .01 vs atrioventricular sequential pacing alone) [27].
  • Midodrine significantly increased both systolic (P < 0.001) and diastolic (P < 0.001) standing blood pressure over placebo (P < 0.001) and ephedrine (P < 0.05) [28].
  • While urinary pH remained alkaline, renal excretion of pseudoephedrine and its metabolite, norpseudoephedrine, was directly correlated with the flow rate of urine in each subject [29].
  • An additional increase of FEV above baseline of 23% for terbutaline and 12% for ephedrine was noted after daily medication [30].
  • RESULTS: Herbal asthma self-treatment was reported by 46 (8%; 95% confidence interval [CI] 6% to 10%); coffee or black tea self-treatment by 36 (6%; 95% CI 4% to 8%), epinephrine or ephedrine OTC use by 36 (6%; 95% CI 4% to 8%), and any of the three practices by 98 subjects (16%; 95% CI 13% to 19%) [31].



Analytical, diagnostic and therapeutic context of PSEUDOEPHEDRINE


  1. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. Shekelle, P.G., Hardy, M.L., Morton, S.C., Maglione, M., Mojica, W.A., Suttorp, M.J., Rhodes, S.L., Jungvig, L., Gagné, J. JAMA (2003) [Pubmed]
  2. Toxicity of over-the-counter stimulants. Pentel, P. JAMA (1984) [Pubmed]
  3. Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects. Tinkelman, D.G., Avner, S.E. JAMA (1977) [Pubmed]
  4. A comparative study of bronchodilator effects of carbuterol and ephedrine. James, T.D., Lyons, H.A. JAMA (1979) [Pubmed]
  5. Fluorescein leakage: First sign of juvenile diabetic retinopathy. Dorchy, H., Toussaint, D. Lancet (1978) [Pubmed]
  6. Intracerebral hemorrhage and vasculitis related to ephedrine abuse. Wooten, M.R., Khangure, M.S., Murphy, M.J. Ann. Neurol. (1983) [Pubmed]
  7. Stroke associated with ephedrine use. Bruno, A., Nolte, K.B., Chapin, J. Neurology (1993) [Pubmed]
  8. The effect of ephedrine plus caffeine on smoking cessation and postcessation weight gain. Nørregaard, J., Jørgensen, S., Mikkelsen, K.L., Tønnesen, P., Iversen, E., Sørensen, T., Søeberg, B., Jakobsen, H.B. Clin. Pharmacol. Ther. (1996) [Pubmed]
  9. Dopamine-like properties of ephedrine in rat brain. Zarrindast, M.R. Br. J. Pharmacol. (1981) [Pubmed]
  10. Dopaminergic agonist properties of ephedrine--theoretical implications. Angrist, B., Rotrosen, J., Kleinberg, D., Merriam, V., Gershon, S. Psychopharmacology (Berl.) (1977) [Pubmed]
  11. JAMA patient page. Ephedra and ephedrine. Torpy, J.M., Lynm, C., Glass, R.M. JAMA (2003) [Pubmed]
  12. Ephedrine and postoperative hyperamylasaemia in obstetrics. Minakami, H., Koike, T., Sugimura, M., Watanabe, T., Tamada, T. Lancet (1993) [Pubmed]
  13. Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure. Limitations and hazards. Davies, B., Bannister, R., Sever, P. Lancet (1978) [Pubmed]
  14. Arrhythmogenic effects of orally administered bronchodilators. Banner, A.S., Sunderrajan, E.V., Agarwal, M.K., Addington, W.W. Arch. Intern. Med. (1979) [Pubmed]
  15. A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. Glynn, C., Dawson, D., Sanders, R. Pain (1988) [Pubmed]
  16. Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. Lowell, B.B., Napolitano, A., Usher, P., Dulloo, A.G., Rosen, B.S., Spiegelman, B.M., Flier, J.S. Endocrinology (1990) [Pubmed]
  17. beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. January, B., Seibold, A., Whaley, B., Hipkin, R.W., Lin, D., Schonbrunn, A., Barber, R., Clark, R.B. J. Biol. Chem. (1997) [Pubmed]
  18. Cardiovascular effects of pseudoephedrine in medically controlled hypertensive patients. Beck, R.A., Mercado, D.L., Seguin, S.M., Andrade, W.P., Cushner, H.M. Arch. Intern. Med. (1992) [Pubmed]
  19. Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity. Dulloo, A.G., Miller, D.S. Am. J. Clin. Nutr. (1987) [Pubmed]
  20. The thermogenic properties of ephedrine/methylxanthine mixtures: animal studies. Dulloo, A.G., Miller, D.S. Am. J. Clin. Nutr. (1986) [Pubmed]
  21. Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. Astrup, A., Lundsgaard, C., Madsen, J., Christensen, N.J. Am. J. Clin. Nutr. (1985) [Pubmed]
  22. Ephedrine increases ventricular arrhythmias in conscious dogs after myocardial infarction. Adamson, P.B., Suarez, J., Ellis, E., Kanaly, T., Vanoli, E. J. Am. Coll. Cardiol. (2004) [Pubmed]
  23. Ephedrine-induced intracerebral hemorrhage and central nervous system vasculitis. Yin, P.A. Stroke (1990) [Pubmed]
  24. Absence of the effect of ephedrine on levels of cyclic adenosine monophosphate in human lymphocytes. Lee, T.P., Reed, C.E. J. Allergy Clin. Immunol. (1977) [Pubmed]
  25. Analgesic and hemodynamic effects of intrathecal clonidine as the sole analgesic agent during first stage of labor: a dose-response study. Chiari, A., Lorber, C., Eisenach, J.C., Wildling, E., Krenn, C., Zavrsky, A., Kainz, C., Germann, P., Klimscha, W. Anesthesiology (1999) [Pubmed]
  26. Coronary artery spasm after ephedrine in a patient with high spinal anesthesia. Hirabayashi, Y., Saitoh, K., Fukuda, H., Mitsuhata, H., Shimizu, R. Anesthesiology (1996) [Pubmed]
  27. Carotid sinus hypersensitivity: evaluation of the vasodepressor component. Almquist, A., Gornick, C., Benson, W., Dunnigan, A., Benditt, D.G. Circulation (1985) [Pubmed]
  28. Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension. Fouad-Tarazi, F.M., Okabe, M., Goren, H. Am. J. Med. (1995) [Pubmed]
  29. Renal excretion of pseudoephedrine. Brater, D.C., Kaojarern, S., Benet, L.Z., Lin, E.T., Lockwood, T., Morris, R.C., McSherry, E.J., Melmon, K.L. Clin. Pharmacol. Ther. (1980) [Pubmed]
  30. Cardiopulmonary effects of long-term bronchodilator administration. Wilson, A.F., Novey, H.S., Cloninger, P., Davis, J., White, D. J. Allergy Clin. Immunol. (1976) [Pubmed]
  31. Use of herbal products, coffee or black tea, and over-the-counter medications as self-treatments among adults with asthma. Blanc, P.D., Kuschner, W.G., Katz, P.P., Smith, S., Yelin, E.H. J. Allergy Clin. Immunol. (1997) [Pubmed]
  32. Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Tran, T.M., Friedman, J., Qunaibi, E., Baameur, F., Moore, R.H., Clark, R.B. Mol. Pharmacol. (2004) [Pubmed]
  33. Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans. Liu, Y.L., Toubro, S., Astrup, A., Stock, M.J. Int. J. Obes. Relat. Metab. Disord. (1995) [Pubmed]
  34. Salivary levels of CGRP and VIP in rhinosinusitis and migraine patients. Bellamy, J.L., Cady, R.K., Durham, P.L. Headache. (2006) [Pubmed]
  35. Increase of glutamate/N-methyl-D-aspartate receptor immunodensity in the dentate gyrus of rats following pseudoephedrine administration. Nudmamud-Thanoi, S., Thanoi, S., Sobhon, P. Neurotoxicology (2006) [Pubmed]
  36. Self-medication with pseudoephedrine in a chronically depressed patient. Diaz, M.A., Wise, T.N., Semchyshyn, G.O. The American journal of psychiatry. (1979) [Pubmed]
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