The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Azelastina     4-[(4-chlorophenyl)methyl]-2- (1...

Synonyms: azelastine, Azelastinum, CHEMBL639, SureCN4239, Optivar (TN), ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of azelastine


Psychiatry related information on azelastine


High impact information on azelastine


Chemical compound and disease context of azelastine


Biological context of azelastine

  • In contrast, azelastine had a very low affinity for both beta-receptors and muscarinic receptors with IC50 values greater than 2 logs greater than those determined for beta-agonists and muscarinic antagonists, respectively [14].
  • Drugs such as terfenadine and azelastine inhibit early bronchoconstriction and to some extent the late-phase asthmatic response as well [15].
  • The geometric means of the dose of histamine (in cumulative breath units [cbu]) necessary to increase specific airway resistance by 100% as compared with baseline (PD100SRaw) were 8.7 and 8.5 cbu before placebo and azelastine, respectively [16].
  • After a histamine inhalation test, we randomly administered either placebo or a single oral dose of 8.8 mg azelastine in a double-blind crossover fashion [16].
  • In parallel with actions on twitch contractions, azelastine suppressed the amplitude of excitatory junction potentials of dog trachea without changing the resting membrane potential and input resistance of smooth muscle cells [17].

Anatomical context of azelastine


Associations of azelastine with other chemical compounds


Gene context of azelastine


Analytical, diagnostic and therapeutic context of azelastine


  1. Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line: evidence for differential regulation of TNF-alpha release, transcription, and degranulation. Hide, I., Toriu, N., Nuibe, T., Inoue, A., Hide, M., Yamamoto, S., Nakata, Y. J. Immunol. (1997) [Pubmed]
  2. A double-blind, controlled trial to assess the safety and efficacy of azelastine nasal spray in seasonal allergic rhinitis. Ratner, P.H., Findlay, S.R., Hampel, F., van Bavel, J., Widlitz, M.D., Freitag, J.J. J. Allergy Clin. Immunol. (1994) [Pubmed]
  3. Corticosteroid-sparing effect of azelastine in the management of bronchial asthma. Busse, W.W., Middleton, E., Storms, W., Dockhorn, R.J., Chu, T.J., Grossman, J., Weiler, J.M., Bronsky, E.A., Mansfield, L.E., Bell, T.D., Hemsworth, G.R., Perhach, J.L., D'Eletto, T.A., Dam, A. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  4. The effect of single and multiple dose therapy with azelastine on the immediate asthmatic response to allergen provocation testing. Ollier, S., Gould, C.A., Davies, R.J. J. Allergy Clin. Immunol. (1986) [Pubmed]
  5. Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis. Friedman, B.S., Santiago, M.L., Berkebile, C., Metcalfe, D.D. J. Allergy Clin. Immunol. (1993) [Pubmed]
  6. Investigation of the anti-allergic activity of azelastine on the immediate and late-phase reactions to allergens and histamine using telethermography. De Weck, A.L., Derer, T., Bähre, M. Clin. Exp. Allergy (2000) [Pubmed]
  7. Effects of azelastine hydrochloride, a novel anti-allergic drug, on the central nervous system. Kaneko, T., Kitahara, A., Ozaki, S., Takizawa, K., Yamatsu, K. Arzneimittel-Forschung. (1981) [Pubmed]
  8. Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. Ciprandi, G., Tosca, M.A., Cosentino, C., Riccio, A.M., Passalacqua, G., Canonica, G.W. J. Allergy Clin. Immunol. (2003) [Pubmed]
  9. Management of allergic rhinitis with a combination antihistamine/anti-inflammatory agent. Lieberman, P. J. Allergy Clin. Immunol. (1999) [Pubmed]
  10. Azelastine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. McTavish, D., Sorkin, E.M. Drugs (1989) [Pubmed]
  11. Inhibition of allergic dermal inflammation by the novel imidazopyridazine derivative TAK-427 in a guinea pig experimental model of eczema. Fukuda, S., Midoro, K., Kamei, T., Gyoten, M., Kawano, Y., Ashida, Y., Nagaya, H. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  12. Evaluation of the onset and duration of effect of azelastine eye drops (0.05%) versus placebo in patients with allergic conjunctivitis using an allergen challenge model. Friedlaender, M.H., Harris, J., LaVallee, N., Russell, H., Shilstone, J. Ophthalmology (2000) [Pubmed]
  13. Involvement of thromboxane A2 and histamine in experimental allergic rhinitis of guinea pigs. Yamasaki, M., Matsumoto, T., Fukuda, S., Nakayama, T., Nagaya, H., Ashida, Y. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  14. The interaction of azelastine with human lung histamine H1, beta, and muscarinic receptor-binding sites. Casale, T.B. J. Allergy Clin. Immunol. (1989) [Pubmed]
  15. Antihistamines in asthma. Holgate, S.T., Finnerty, J.P. J. Allergy Clin. Immunol. (1989) [Pubmed]
  16. Duration of the effect of a single dose of azelastine on histamine-induced bronchoconstriction. Magnussen, H., Reuss, G., Jörres, R., Aurich, R. J. Allergy Clin. Immunol. (1989) [Pubmed]
  17. Effects of azelastine on vagal neuroeffector transmission in canine and human airway smooth muscle. Aizawa, H., Inoue, H., Miyazaki, N., Ikeda, T., Shigematsu, N., Ito, Y. J. Allergy Clin. Immunol. (1990) [Pubmed]
  18. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. Ciprandi, G., Pronzato, C., Passalacqua, G., Ricca, V., Grögen, J., Mela, G.S., Varese, P., Bertolini, C., Bagnasco, M., Canonica, G.W. J. Allergy Clin. Immunol. (1996) [Pubmed]
  19. The effect of azelastine on neutrophil and eosinophil generation of superoxide. Busse, W., Randlev, B., Sedgwick, J. J. Allergy Clin. Immunol. (1989) [Pubmed]
  20. Azelastine inhibits IgE-mediated human basophil histamine release. Little, M.M., Casale, T.B. J. Allergy Clin. Immunol. (1989) [Pubmed]
  21. Inhibition by azelastine of nonallergic histamine release from rat peritoneal mast cells. Fields, D.A., Pillar, J., Diamantis, W., Perhach, J.L., Sofia, R.D., Chand, N. J. Allergy Clin. Immunol. (1984) [Pubmed]
  22. Multicenter, double-blind, multiple-dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis. Weiler, J.M., Donnelly, A., Campbell, B.H., Connell, J.T., Diamond, L., Hamilton, L.H., Rosenthal, R.R., Hemsworth, G.R., Perhach, J.L. J. Allergy Clin. Immunol. (1988) [Pubmed]
  23. Effect of intranasal azelastine and beclomethasone dipropionate on nasal symptoms, nasal cytology, and bronchial responsiveness to methacholine in allergic rhinitis in response to grass pollens. Pelucchi, A., Chiapparino, A., Mastropasqua, B., Marazzini, L., Hernandez, A., Foresi, A. J. Allergy Clin. Immunol. (1995) [Pubmed]
  24. Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes. Nakajima, M., Ohyama, K., Nakamura, S., Shimada, N., Yamazaki, H., Yokoi, T. Drug Metab. Dispos. (1999) [Pubmed]
  25. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Nakajima, M., Nakamura, S., Tokudome, S., Shimada, N., Yamazaki, H., Yokoi, T. Drug Metab. Dispos. (1999) [Pubmed]
  26. Efficacy of azelastine in perennial allergic rhinitis: clinical and rhinomanometric evaluation. Meltzer, E.O., Storms, W.W., Pierson, W.E., Cummins, L.H., Orgel, H.A., Perhach, J.L., Hemsworth, G.R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  27. A dose-response study of the bronchodilator action of azelastine in asthma. Kemp, J.P., Meltzer, E.O., Orgel, H.A., Welch, M.J., Bucholtz, G.A., Middleton, E., Spector, S.L., Newton, J.J., Perhach, J.L. J. Allergy Clin. Immunol. (1987) [Pubmed]
  28. Intranasal azelastine. A review of its efficacy in the management of allergic rhinitis. McNeely, W., Wiseman, L.R. Drugs (1998) [Pubmed]
WikiGenes - Universities