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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The in vivo effect of 2,6-xylidine on induction of micronuclei in mouse bone marrow cells.

The ability of 2,6-xylidine to produce chromosome breakage and/or spindle malformation in vivo was evaluated by an assessment of the capacity of the compound to induce micronuclei in bone marrow polychromatic erythrocytes. Male ICR mice were administered a single oral dose of 350, 175 or 87.5 mg/kg of 2,6-xylidine by oral gavage and bone marrow was extracted from the femurs 24, 48 and 72 h thereafter. The frequency of micronuclei in animals treated with 2,6-xylidine was not different from that observed for the corresponding solvent treated controls.[1]

References

  1. The in vivo effect of 2,6-xylidine on induction of micronuclei in mouse bone marrow cells. Parton, J.W., Probst, G.S., Garriott, M.L. Mutat. Res. (1988) [Pubmed]
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