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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Viral myb oncogene encodes a sequence-specific DNA-binding activity.

The retroviral oncogene v-myb and its cellular progenitor c-myb encode nuclear DNA-binding proteins. Myb genes have been identified in a broad range of species, including vertebrates, the fruit fly Drosophila melanogaster and the plant Zea mays. The localization of the DNA-binding domain of the v-MYB protein to the highly conserved amino-terminal region suggests that the MYB/DNA interaction is important for MYB function. We show here that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG. So like other nuclear transforming proteins, v-MYB seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.[1]

References

  1. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Biedenkapp, H., Borgmeyer, U., Sippel, A.E., Klempnauer, K.H. Nature (1988) [Pubmed]
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