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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Drosophila


Psychiatry related information on Drosophila


High impact information on Drosophila

  • Myb genes have been identified in a broad range of species, including vertebrates, the fruit fly Drosophila melanogaster and the plant Zea mays [4].
  • Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription [5].
  • The products of the Drosophila segment polarity gene armadillo and its vertebrate homologue beta-catenin are components of the signal transduction pathway for Wingless/Wnt-1; this signal regulates cell-fate choices in embryos of the fruit fly Drosophila and vertebrates [6].
  • Recent studies in the fruit-fly Drosophila melanogaster show how protein complexes that bind to 'GAGA' DNA elements can replace nucleosomes to create a local chromatin environment that facilitates a variety of site-specific regulatory responses [7].
  • Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration [8].

Biological context of Drosophila


Anatomical context of Drosophila


Associations of Drosophila with chemical compounds


Gene context of Drosophila


  1. Simian virus 40 origin- and T-antigen-dependent DNA replication with Drosophila factors in vitro. Kamakaka, R.T., Kaufman, P.D., Stillman, B., Mitsis, P.G., Kadonaga, J.T. Mol. Cell. Biol. (1994) [Pubmed]
  2. Damage-resistant DNA synthesis in eukaryotes. Lavin, M.F., Schroeder, A.L. Mutat. Res. (1988) [Pubmed]
  3. Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. Rieger, D., Stanewsky, R., Helfrich-Förster, C. J. Biol. Rhythms (2003) [Pubmed]
  4. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Biedenkapp, H., Borgmeyer, U., Sippel, A.E., Klempnauer, K.H. Nature (1988) [Pubmed]
  5. Myc and Max homologs in Drosophila. Gallant, P., Shiio, Y., Cheng, P.F., Parkhurst, S.M., Eisenman, R.N. Science (1996) [Pubmed]
  6. Cell adhesion and signal transduction: the Armadillo connection. Peifer, M. Trends Cell Biol. (1995) [Pubmed]
  7. Anything else but GAGA: a nonhistone protein complex reshapes chromatin structure. Lehmann, M. Trends Genet. (2004) [Pubmed]
  8. The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle. Korhonen, L., Lindholm, D. J. Cell Biol. (2004) [Pubmed]
  9. ERECT WING, the Drosophila member of a family of DNA binding proteins is required in imaginal myoblasts for flight muscle development. DeSimone, S., Coelho, C., Roy, S., VijayRaghavan, K., White, K. Development (1996) [Pubmed]
  10. Myc, cell competition, and compensatory proliferation. Gallant, P. Cancer Res. (2005) [Pubmed]
  11. Functional characterization of a second porin isoform in Drosophila melanogaster. DmPorin2 forms voltage-independent cation-selective pores. Aiello, R., Messina, A., Schiffler, B., Benz, R., Tasco, G., Casadio, R., De Pinto, V. J. Biol. Chem. (2004) [Pubmed]
  12. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Foley, E., O'Farrell, P.H., Sprenger, F. Curr. Biol. (1999) [Pubmed]
  13. A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Schaefer, M., Shevchenko, A., Shevchenko, A., Knoblich, J.A. Curr. Biol. (2000) [Pubmed]
  14. Cis-acting sequences contributing to expression of the Drosophila affinidisjuncta Adh gene in both larvae and adults. McKenzie, R.W., Brennan, M.D. Insect Biochem. Mol. Biol. (1998) [Pubmed]
  15. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Abarca, C., Albrecht, U., Spanagel, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis. Gaziova, I., Bonnette, P.C., Henrich, V.C., Jindra, M. Development (2004) [Pubmed]
  17. Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. Zheng, Y., Hirschberg, B., Yuan, J., Wang, A.P., Hunt, D.C., Ludmerer, S.W., Schmatz, D.M., Cully, D.F. J. Biol. Chem. (2002) [Pubmed]
  18. Evolutionary conservation of synaptosome-associated protein 25 kDa (SNAP-25) shown by Drosophila and Torpedo cDNA clones. Risinger, C., Blomqvist, A.G., Lundell, I., Lambertsson, A., Nässel, D., Pieribone, V.A., Brodin, L., Larhammar, D. J. Biol. Chem. (1993) [Pubmed]
  19. Selective high-affinity transport of aspartate by a Drosophila homologue of the excitatory amino-acid transporters. Besson, M.T., Soustelle, L., Birman, S. Curr. Biol. (2000) [Pubmed]
  20. Drosophila glucosylceramide synthase: a negative regulator of cell death mediated by proapoptotic factors. Kohyama-Koganeya, A., Sasamura, T., Oshima, E., Suzuki, E., Nishihara, S., Ueda, R., Hirabayashi, Y. J. Biol. Chem. (2004) [Pubmed]
  21. Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Fanto, M., Weber, U., Strutt, D.I., Mlodzik, M. Curr. Biol. (2000) [Pubmed]
  22. The progeny of wingless-expressing cells deliver the signal at a distance in Drosophila embryos. Pfeiffer, S., Alexandre, C., Calleja, M., Vincent, J.P. Curr. Biol. (2000) [Pubmed]
  23. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Wharton, K.A., Zimmermann, G., Rousset, R., Scott, M.P. Dev. Biol. (2001) [Pubmed]
  24. Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects. Fluegel, M.L., Parker, T.J., Pallanck, L.J. Genetics (2006) [Pubmed]
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