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Gene Review

MYB  -  v-myb avian myeloblastosis viral oncogene...

Homo sapiens

Synonyms: Cmyb, Proto-oncogene c-Myb, Transcriptional activator Myb, c-myb, c-myb_CDS, ...
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Disease relevance of MYB


High impact information on MYB


Chemical compound and disease context of MYB


Biological context of MYB


Anatomical context of MYB


Associations of MYB with chemical compounds

  • Replacement of lysine by arginine at all of these sites dramatically decreased the trans-activating capacity of c-Myb [25].
  • In particular, a region toward the NH2 terminus of the protein containing a 3-fold tandem repeat of 51 residues is evolutionarily conserved and is the only region of homology with the Drosophila c-myb protein [26].
  • We have found that the human c-erbB-2 promoter activity is repressed by c-Myb or B-Myb in a chloramphenicol acetyltransferase co-transfection assay [27].
  • PH4 of Petunia Is an R2R3 MYB Protein That Activates Vacuolar Acidification through Interactions with Basic-Helix-Loop-Helix Transcription Factors of the Anthocyanin Pathway [28].
  • Also, growth of representative lines in vitro was inhibited in a dose- and sequence-dependent manner by targeting the MYB gene with unmodified or phosphorothioate-modified antisense oligodeoxynucleotides [29].

Physical interactions of MYB


Regulatory relationships of MYB


Other interactions of MYB

  • We found that c-myb was elevated in AML and ALL samples, but NmU expression was increased only in AML cells [1].
  • Three members of the human myb gene family (c-myb, A-myb, and B-myb) encode transcriptional regulators that can bind to specific DNA sequences [40].
  • In addition, p53 stimulates the degradation of c-Myb through a proteasome-dependent mechanism, which is, at least partly, mediated by induction of Siah in certain types of cells [18].
  • These data suggest that amplification of c-myb in tumor cells may lead to robust GRP78 gene induction, which may in turn assist cells in survival under conditions of oxygen deprivation and nutrient stress [35].
  • Regulation of GM-CSF expression by c-myb was due in part to transactivation of the GM-CSF promoter [22].

Analytical, diagnostic and therapeutic context of MYB


  1. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Shetzline, S.E., Rallapalli, R., Dowd, K.J., Zou, S., Nakata, Y., Swider, C.R., Kalota, A., Choi, J.K., Gewirtz, A.M. Blood (2004) [Pubmed]
  2. Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression. Greco, C., Alvino, S., Buglioni, S., Assisi, D., Lapenta, R., Grassi, A., Stigliano, V., Mottolese, M., Casale, V. Anticancer Res. (2001) [Pubmed]
  3. More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Steensma, D.P., Pardanani, A., Stevenson, W.S., Hoyt, R., Kiu, H., Grigg, A.P., Szer, J., Juneja, S., Hilton, D.J., Alexander, W.S., Roberts, A.W. Blood (2006) [Pubmed]
  4. Studies of the human c-myb gene and its product in human acute leukemias. Slamon, D.J., Boone, T.C., Murdock, D.C., Keith, D.E., Press, M.F., Larson, R.A., Souza, L.M. Science (1986) [Pubmed]
  5. c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression. Thompson, M.A., Rosenthal, M.A., Ellis, S.L., Friend, A.J., Zorbas, M.I., Whitehead, R.H., Ramsay, R.G. Cancer Res. (1998) [Pubmed]
  6. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Clappier, E., Cuccuini, W., Kalota, A., Crinquette, A., Cayuela, J.M., Dik, W.A., Langerak, A.W., Montpellier, B., Nadel, B., Walrafen, P., Delattre, O., Aurias, A., Leblanc, T., Dombret, H., Gewirtz, A.M., Baruchel, A., Sigaux, F., Soulier, J. Blood (2007) [Pubmed]
  7. Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Drabsch, Y., Hugo, H., Zhang, R., Dowhan, D.H., Miao, Y.R., Gewirtz, A.M., Barry, S.C., Ramsay, R.G., Gonda, T.J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  8. Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Weston, K., Bishop, J.M. Cell (1989) [Pubmed]
  9. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Cooper, J.P., Nimmo, E.R., Allshire, R.C., Cech, T.R. Nature (1997) [Pubmed]
  10. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Biedenkapp, H., Borgmeyer, U., Sippel, A.E., Klempnauer, K.H. Nature (1988) [Pubmed]
  11. Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. Harper, M.E., Franchini, G., Love, J., Simon, M.I., Gallo, R.C., Wong-Staal, F. Nature (1983) [Pubmed]
  12. Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU. Kavgaci, H., Ozdemir, F., Ovali, E., Yavuz, A., Yavuz, M., Aydin, F. Chemotherapy. (2005) [Pubmed]
  13. Patterns of regulation of nuclear proto-oncogenes MYCN and MYB in retinoic acid treated neuroblastoma cells. Thiele, C.J. Prog. Clin. Biol. Res. (1991) [Pubmed]
  14. Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Weber, B.L., Westin, E.H., Clarke, M.F. Science (1990) [Pubmed]
  15. Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells. Neckers, L.M., Bauer, S., McGlennen, R.C., Trepel, J.B., Rao, K., Greene, W.C. Mol. Cell. Biol. (1986) [Pubmed]
  16. Modulation of c-myb transcription in autoimmune disease by cyclophosphamide. Mountz, J.D., Mushinski, J.F., Smith, H.R., Klinman, D.M., Steinberg, A.D. J. Immunol. (1985) [Pubmed]
  17. Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage. Nicot, C., Mahieux, R., Pise-Masison, C., Brady, J., Gessain, A., Yamaoka, S., Franchini, G. Mol. Cell. Biol. (2001) [Pubmed]
  18. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. Tanikawa, J., Ichikawa-Iwata, E., Kanei-Ishii, C., Nakai, A., Matsuzawa, S., Reed, J.C., Ishii, S. J. Biol. Chem. (2000) [Pubmed]
  19. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Kurahashi, T., Nomura, T., Kanei-Ishii, C., Shinkai, Y., Ishii, S. Mol. Biol. Cell (2005) [Pubmed]
  20. p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A. Tanikawa, J., Nomura, T., Macmillan, E.M., Shinagawa, T., Jin, W., Kokura, K., Baba, D., Shirakawa, M., Gonda, T.J., Ishii, S. J. Biol. Chem. (2004) [Pubmed]
  21. Characterization of the c-Myb-responsive region and regulation of the human type I collagen alpha 2 chain gene by c-Myb. Luchetti, M.M., Paroncini, P., Majlingovà, P., Frampton, J., Mucenski, M., Baroni, S.S., Sambo, P., Golay, J., Introna, M., Gabrielli, A. J. Biol. Chem. (2003) [Pubmed]
  22. Regulation of proliferation and cytokine expression of bone marrow fibroblasts: role of c-myb. Szczylik, C., Skorski, T., Ku, D.H., Nicolaides, N.C., Wen, S.C., Rudnicka, L., Bonati, A., Malaguarnera, L., Calabretta, B. J. Exp. Med. (1993) [Pubmed]
  23. C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. Verbeek, W., Gombart, A.F., Chumakov, A.M., Müller, C., Friedman, A.D., Koeffler, H.P. Blood (1999) [Pubmed]
  24. Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb. Xu, H., Inouye, M., Hines, E.R., Collins, J.F., Ghishan, F.K. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  25. Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation. Sano, Y., Ishii, S. J. Biol. Chem. (2001) [Pubmed]
  26. Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Majello, B., Kenyon, L.C., Dalla-Favera, R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  27. c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter. Mizuguchi, G., Kanei-Ishii, C., Takahashi, T., Yasukawa, T., Nagase, T., Horikoshi, M., Yamamoto, T., Ishii, S. J. Biol. Chem. (1995) [Pubmed]
  28. PH4 of Petunia Is an R2R3 MYB Protein That Activates Vacuolar Acidification through Interactions with Basic-Helix-Loop-Helix Transcription Factors of the Anthocyanin Pathway. Quattrocchio, F., Verweij, W., Kroon, A., Spelt, C., Mol, J., Koes, R. Plant Cell (2006) [Pubmed]
  29. Biologic and therapeutic significance of MYB expression in human melanoma. Hijiya, N., Zhang, J., Ratajczak, M.Z., Kant, J.A., DeRiel, K., Herlyn, M., Zon, G., Gewirtz, A.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  30. Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. Sala, A., Casella, I., Grasso, L., Bellon, T., Reed, J.C., Miyashita, T., Peschle, C. Cancer Res. (1996) [Pubmed]
  31. Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells. Fenstermaker, R.A., Ciesielski, M.J., Castiglia, G.J. Oncogene (1998) [Pubmed]
  32. Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. Keough, R., Woollatt, E., Crawford, J., Sutherland, G.R., Plummer, S., Casey, G., Gonda, T.J. Genomics (1999) [Pubmed]
  33. The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells. Kenney, S.C., Holley-Guthrie, E., Quinlivan, E.B., Gutsch, D., Zhang, Q., Bender, T., Giot, J.F., Sergeant, A. Mol. Cell. Biol. (1992) [Pubmed]
  34. The c-myb proto-oncogene product binds to but does not activate the promoter of the DNA polymerase alpha gene. Sudo, T., Miyazawa, H., Hanaoka, F., Ishii, S. Oncogene (1992) [Pubmed]
  35. Expression of stress response protein glucose regulated protein-78 mediated by c-Myb. Ramsay, R.G., Ciznadija, D., Mantamadiotis, T., Anderson, R., Pearson, R. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  36. Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence. Yamaki, A., Tochigi, J., Kudoh, J., Minoshima, S., Shimizu, N., Shimizu, Y. Gene (2001) [Pubmed]
  37. Growth arrest and terminal differentiation of leukemic myelomonocytic cells induced through ligation of surface CD23 antigen. Ouaaz, F., Sola, B., Issaly, F., Kolb, J.P., Davi, F., Mentz, F., Arock, M., Paul-Eugène, N., Körner, M., Dugas, B. Blood (1994) [Pubmed]
  38. Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Qin, J.Z., Zhang, C.L., Kamarashev, J., Dummer, R., Burg, G., Döbbeling, U. Blood (2001) [Pubmed]
  39. Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. Kanei-Ishii, C., Nomura, T., Takagi, T., Watanabe, N., Nakayama, K.I., Ishii, S. J. Biol. Chem. (2008) [Pubmed]
  40. Functional domains of the human B-myb gene product. Nakagoshi, H., Takemoto, Y., Ishii, S. J. Biol. Chem. (1993) [Pubmed]
  41. Identification of alternatively spliced transcripts for human c-myb: molecular cloning and sequence analysis of human c-myb exon 9A sequences. Dasgupta, P., Reddy, E.P. Oncogene (1989) [Pubmed]
  42. Sublocalization of c-myb to 6q21----q23 by in situ hybridization and c-myb expression in a human teratocarcinoma with 6q rearrangements. Janssen, J.W., Vernole, P., de Boer, P.A., Oosterhuis, J.W., Collard, J.G. Cytogenet. Cell Genet. (1986) [Pubmed]
  43. Distinct cellular factors regulate the c-myb promoter through its E2F element. Campanero, M.R., Armstrong, M., Flemington, E. Mol. Cell. Biol. (1999) [Pubmed]
  44. c-Myb protein interacts with Rcd-1, a component of the CCR4 transcription mediator complex. Haas, M., Siegert, M., Schürmann, A., Sodeik, B., Wolfes, H. Biochemistry (2004) [Pubmed]
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