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Panayotides, P. et al.

Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia.

In a case of prolymphocytic leukemia (PLL), receptors for interleukin-2 (IL-2R) were demonstrated by immunofluorescence with a monoclonal antibody against IL-2R. Highly purified leukemic B-cells, cultured in vitro with recombinant IL-2 (r-IL-2), responded to IL-2 with a marked increase of DNA-synthesis. Both spontaneous and r-IL-2-induced proliferation of leukemic cells were totally abrogated by the anti-IL-2R monoclonal antibody.[1]

References

Interleukin-2 can induce proliferation of leukemic B-cells in prolymphocytic leukemia. Panayotides, P., Porwit, A., Lenkei, R., Reizenstein, P. Eur. J. Haematol. (1987) [Pubmed]

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