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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Diffusing lung capacity and cyclosporine in patients with heart transplants.

Pulmonary function studies were performed in 10 patients undergoing surgery for heart transplantation. The study was repeated 6 to 12 months after surgery. The comparison between data before and after transplantation showed an overall improvement in lung function indices, except for the lung diffusing capacity (DLCO). A mean 14% reduction (p less than 0.01) of DLCO was observed. In the absence of evidence of other lung disease or rejection reaction in these patients, this finding may be related to a side effect of cyclosporine on the lung and deserves further investigation.[1]


  1. Diffusing lung capacity and cyclosporine in patients with heart transplants. Casan, P., Sanchis, J., Cladellas, M., Amengual, M.J., Caralps, J.M. The Journal of heart transplantation. (1987) [Pubmed]
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