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Gene Review

PLF  -  Pulmonary function

Homo sapiens

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Disease relevance of PLF


Psychiatry related information on PLF


High impact information on PLF


Chemical compound and disease context of PLF

  • Second-line chemotherapy of advanced disseminated gastric cancer after cisplatin, infusional 5-fluorouracil, folinic acid (PLF): benefit dependent on progression-free interval after first-line therapy [15].
  • The objective of this study was to evaluate the toxicity and efficacy of neoadjuvant chemotherapy using the PLF (cisplatin/leucovorin [folinic acid]/5-fluorouracil [FU]) regimen in these patients [16].
  • CONCLUSION: Ambulatory infusional PLF with carboplatin or cisplatin using sequentially alternating delivery of the component antineoplastic agents is feasible and active with minimal toxicity [17].
  • The majority of reviewed medical evidence suggests that interbody techniques are associated with higher fusion rates compared with PLF when applied to patients with low-back pain due to DDD limited to one or two levels [18].
  • OBJECTIVES: To document tensile transmission to the PLF and MLF when traction was applied to latissimus dorsi (LD), gluteus maximus (GM), external and internal oblique (EO, IO), and transversus abdominis (TrA) in unembalmed cadavers [19].

Biological context of PLF

  • PLF binds to the active site of human DHFR since methotrexate (MTX) competes stoichiometrically and the denatured enzyme in the presence of PLF did not exhibit fluorescent enhancement [20].
  • A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4'-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP) [20].
  • We used two novel methods of spectral analysis of HRV: 1) the high-frequency (HF) spectral component, V(index), calculated as an average HF power from the most linear portion of HF power versus the R-R interval regression curve, and 2) the prevalent low-frequency oscillation of heart rate (PLF) [21].
  • Furthermore, the molar gestation group's low serum PLF levels remained unchanged throughout the entire follow-up period and until their beta-human chorionic gonadotrophin levels were undetectable [4].
  • Placental isoferritin (PLF) has been shown to be involved in the down-regulation of the maternal immune system during pregnancy [22].

Anatomical context of PLF

  • PLF was found on a subset of CD8 lymphocytes and appeared to block detection of the CD8 antigen by specific monoclonal antibodies [1].
  • These observations strongly suggest that transepidermal migration of leukocytes in psoriatic lesions is provoked by PLF, whose activity appears to reflect that of complement cleavage products, particularly C3a, presumably produced by complement activation in the subcorneal region of the epidermis [23].
  • We have investigated the presence of PLF in the human embryo and early fetus and its secretion into amniotic fluid (AF) and fetal blood [24].
  • The detection of the p43-PLF immunomodulator protein in macrophages at a very early stage of embryonic development and its very low concentration in fetal blood suggests that its immunoregulatory role is limited to the feto-maternal interface [24].
  • Positive p43-PLF immunostaining was found from 7 weeks gestation in proximal tubules of the primitive nephron and macrophages of the liver sinusoids, blood vessels and mesenchymal tissue [24].

Associations of PLF with chemical compounds

  • Elution of PLF by incubation with levamisole, but not by culture medium alone, led to the unblocking of the CD8 determinant on these cells [1].
  • The KD values for both H2PLF and PLF indicate that the fluorescein moiety does not significantly affect folate binding in enzyme binary complexes.(ABSTRACT TRUNCATED AT 250 WORDS)[20]
  • Chemotherapy consisted of 1-day per week administration of intravenous cisplatin 35 mg m(-2), 6S-stereoisomer leucovorin 250 mg m(-2) and fluorouracil 500 mg m(-2) (PLF) [25].
  • CONCLUSIONS: The presented PLF protocol yields R-0 resection rates comparable to protocols like EAP (etoposide, adriamycin, platinum), but with a better safety profile allowing administration in an outpatient setting [2].
  • Venous blood was obtained from both groups for PLF determination before evacuation of the pregnancy products. beta-Human chorionic gonadotrophin (HCG), 17 beta-oestradiol and progesterone were determined at surgery for the tubal pregnancy patients [22].

Regulatory relationships of PLF


Other interactions of PLF

  • Biglycan mRNA expression was strong in the PLF, moderate in the GF and weak in the RTF [28].
  • Furthermore, PLF down-regulated cell surface expression of CEA-related CD66 antigen on both these cell lines [26].
  • Periodontal-ligament (PLF) and gingival fibroblasts responded to recombinant human IL1 beta and to media conditioned by LPS-stimulated mononuclear phagocytes by secreting prostaglandin E (PGE) [29].
  • Binding of PLF to human DHFR or human placental m-FBP results in approximately a 20-fold enhancement in the magnitude of the fluorescence emission, suggesting that the ligand interacts with a hydrophobic region on these proteins [20].
  • No correlation was found between the other measured pregnancy hormones and PLF for the tubal pregnancy group [22].

Analytical, diagnostic and therapeutic context of PLF


  1. Isoferritins in HIV infection: relation to clinical stage, CD8 lymphocyte binding and the pathogenesis of AIDS. Moroz, C., Misrock, S.L., Siegal, F.P. AIDS (1989) [Pubmed]
  2. Low toxic neoadjuvant cisplatin, 5-fluorouracil and folinic acid in locally advanced gastric cancer yields high R-0 resection rate. Menges, M., Schmidt, C., Lindemann, W., Ridwelski, K., Pueschel, W., Jüngling, B., Feifel, G., Schilling, M., Stallmach, A., Zeitz, M. J. Cancer Res. Clin. Oncol. (2003) [Pubmed]
  3. Placental isoferritin associated p43 antigen correlates with features of high differentiation in breast cancer. Rosen, H.R., Moroz, C., Reiner, A., Reinerova, M., Stierer, M., Svec, J., Schemper, M., Jakesz, R. Breast Cancer Res. Treat. (1992) [Pubmed]
  4. Placental isoferritin levels during first trimester of normal and complete molar gestations. Maymon, R., Weinraub, Z., Bukovsky, I., Moroz, C. Placenta (1995) [Pubmed]
  5. Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in patients with chronic obstructive pulmonary disease. Ries, A.L., Kaplan, R.M., Limberg, T.M., Prewitt, L.M. Ann. Intern. Med. (1995) [Pubmed]
  6. Respiratory and hemodynamic study during wakefulness and sleep in myotonic dystrophy. Guilleminault, C., Cummiskey, J., Motta, J., Lynne-Davies, P. Sleep. (1978) [Pubmed]
  7. Pulmonary function, smoking cessation and 30 year mortality in middle aged Finnish men. Pelkonen, M., Tukiainen, H., Tervahauta, M., Notkola, I.L., Kivelä, S.L., Salorinne, Y., Nissinen, A. Thorax (2000) [Pubmed]
  8. Pulmonary function and alcohol consumption. Neukirch, F., Liard, R., Korobaeff, M., Pariente, R. Chest (1990) [Pubmed]
  9. Pulmonary function, nutrition, and self-concept in cystic fibrosis summer campers. Rubin, B.K., Geiger, D.W. Chest (1991) [Pubmed]
  10. Improvement in pulmonary function and elastic recoil after lung-reduction surgery for diffuse emphysema. Sciurba, F.C., Rogers, R.M., Keenan, R.J., Slivka, W.A., Gorcsan, J., Ferson, P.F., Holbert, J.M., Brown, M.L., Landreneau, R.J. N. Engl. J. Med. (1996) [Pubmed]
  11. Efficacy of aerosolized tobramycin in patients with cystic fibrosis. Ramsey, B.W., Dorkin, H.L., Eisenberg, J.D., Gibson, R.L., Harwood, I.R., Kravitz, R.M., Schidlow, D.V., Wilmott, R.W., Astley, S.J., McBurnie, M.A. N. Engl. J. Med. (1993) [Pubmed]
  12. Pulmonary arteriovenous malformations. Physiologic observations and results of therapeutic balloon embolization. Terry, P.B., White, R.I., Barth, K.H., Kaufman, S.L., Mitchell, S.E. N. Engl. J. Med. (1983) [Pubmed]
  13. Pulmonary function and airway responsiveness during long-term therapy with captopril. Boulet, L.P., Milot, J., Lampron, N., Lacourcière, Y. JAMA (1989) [Pubmed]
  14. Treatment of chronic obstructive pulmonary disease with orally administered theophylline. A double-blind, controlled study. Alexander, M.R., Dull, W.L., Kasik, J.E. JAMA (1980) [Pubmed]
  15. Second-line chemotherapy of advanced disseminated gastric cancer after cisplatin, infusional 5-fluorouracil, folinic acid (PLF): benefit dependent on progression-free interval after first-line therapy. Stahl, M., Müller, C., Köster, W., Wilke, H. Onkologie. (2005) [Pubmed]
  16. Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study. Ott, K., Sendler, A., Becker, K., Dittler, H.J., Helmberger, H., Busch, R., Kollmannsberger, C., Siewert, J.R., Fink, U. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. (2003) [Pubmed]
  17. Pilot study of ambulatory infusional delivery of a multidrug regimen: cisplatin, 5-fluorouracil and leucovorin (PFL) +/- etoposide. Lokich, J., Anderson, N., Moore, C., Bern, M., Coco, F., Dow, E., Zipoli, T., Gonzalves, L. The Journal of infusional chemotherapy. (1996) [Pubmed]
  18. Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 11: interbody techniques for lumbar fusion. Resnick, D.K., Choudhri, T.F., Dailey, A.T., Groff, M.W., Khoo, L., Matz, P.G., Mummaneni, P., Watters, W.C., Wang, J., Walters, B.C., Hadley, M.N. Journal of neurosurgery. Spine. (2005) [Pubmed]
  19. Tensile transmission across the lumbar fasciae in unembalmed cadavers: effects of tension to various muscular attachments. Barker, P.J., Briggs, C.A., Bogeski, G. Spine. (2004) [Pubmed]
  20. Synthesis and biological evaluation of a fluorescent analogue of folic acid. McAlinden, T.P., Hynes, J.B., Patil, S.A., Westerhof, G.R., Jansen, G., Schornagel, J.H., Kerwar, S.S., Freisheim, J.H. Biochemistry (1991) [Pubmed]
  21. Novel spectral indexes of heart rate variability as predictors of sudden and non-sudden cardiac death after an acute myocardial infarction. Kiviniemi, A.M., Tulppo, M.P., Wichterle, D., Hautala, A.J., Tiinanen, S., Seppänen, T., Mäkikallio, T.H., Huikuri, H.V. Ann. Med. (2007) [Pubmed]
  22. Placental isoferritin patterns during normal first trimester and tubal gestations. Maymon, R., Zitzer, P., Manor, Y., Bukovsky, I., Moroz, C. Hum. Reprod. (1995) [Pubmed]
  23. Characterization of a leukotactic factor derived from psoriatic scale. Tagami, H., Ofuji, S. Br. J. Dermatol. (1977) [Pubmed]
  24. Detection of the immunoregulator p43-placental isoferritin in the human embryo and fetus. Maymon, R., Jauniaux, E., Greenwold, N., Traub, L., Moroz, C. Mol. Hum. Reprod. (2000) [Pubmed]
  25. A phase II study of weekly cisplatin, 6S-stereoisomer leucovorin and fluorouracil as first-line chemotherapy for elderly patients with advanced gastric cancer. Graziano, F., Santini, D., Testa, E., Catalano, V., Beretta, G.D., Mosconi, S., Tonini, G., Lai, V., Labianca, R., Cascinu, S. Br. J. Cancer (2003) [Pubmed]
  26. Alterations of cell surface antigens induced by placental isoform of ferritin in human carcinoma cell lines. Sedlak, J., Reinerova, M., Hunakova, L., Ausch, C., Chorvath, B., Rosen, H., Moroz, C. Cancer Lett. (1995) [Pubmed]
  27. The expression of PLF in placenta in pregnancy-induced hypertension and the relationship between the PLF and serum VCAM-1. Xu, X., Xiang, W., Chen, H. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2003) [Pubmed]
  28. Isolation and characterization of fibroblasts derived from regenerating human periodontal defects. Ivanovski, S., Haase, H.R., Bartold, P.M. Arch. Oral Biol. (2001) [Pubmed]
  29. The effects of interleukin 1 on collagenolytic activity and prostaglandin-E secretion by human periodontal-ligament and gingival fibroblast. Richards, D., Rutherford, R.B. Arch. Oral Biol. (1988) [Pubmed]
  30. Placental isoferritin as a physiological downregulator of cellular immunoreactivity during pregnancy. Sirota, L., Kupfer, B., Moroz, C. Clin. Exp. Immunol. (1989) [Pubmed]
  31. Placental isoferritin as a marker of early abortion in pregnancies induced by in vitro fertilization. Fisch, B., Manor, Y., Ovadia, J., Moroz, C. Placenta (1996) [Pubmed]
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