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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells.

Angiotensin II was shown to activate S6-kinase in cultured vascular smooth muscle cells (VSMC) in a dose- (10(-9)-10(-6) M) and time-dependent manner. Pretreatment of quiescent cells with 12-O-Tetradecanoylphorbol-13-acetate had no effect on the activation levels of the kinase at the hormone levels used. However, stimulation of S6-kinase activity by angiotensin II was markedly inhibited by the inclusion of amiloride hydrochloride in serum-free medium during activation procedures. Angiotensin was not mitogenic for VSMC at even the highest doses used (10(-6) M). These findings support the notion that raised intracellular pH results in the activation of protein synthesis in quiescent cells.[1]

References

  1. Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells. Scott-Burden, T., Resink, T.J., Baur, U., Bürgin, M., Bühler, F.R. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
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