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Gene Review

Rps6kb1  -  ribosomal protein S6 kinase, polypeptide 1

Rattus norvegicus

Synonyms: 70 kDa ribosomal protein S6 kinase 1, P70S6K1, Ribosomal protein S6 kinase I, Ribosomal protein S6 kinase beta-1, S6K-beta-1, ...
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Disease relevance of Rps6kb1

  • Selective inhibition of either p70S6K or ERK blocked myocardial hypertrophy [1].
  • Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis [2].
  • These results indicate divergent roles for the ERK and p70S6K pathways in the phenotypic changes associated with cardiac hypertrophy [3].
  • Antiserum raised against rat liver S6 kinase specifically immunoprecipitates the purified 32P-labeled H4 hepatoma insulin-stimulated S6 kinase [4].
  • Here we demonstrate that primary tumors from tuberous sclerosis complex (TSC) patients and the Eker rat model of TSC expressed elevated levels of phosphorylated mammalian target of rapamycin (mTOR) and its effectors: p70S6K, S6 ribosomal protein, 4E-BP1, and eIF4G [5].

Psychiatry related information on Rps6kb1


High impact information on Rps6kb1


Chemical compound and disease context of Rps6kb1


Biological context of Rps6kb1


Anatomical context of Rps6kb1


Associations of Rps6kb1 with chemical compounds


Physical interactions of Rps6kb1


Enzymatic interactions of Rps6kb1


Regulatory relationships of Rps6kb1


Other interactions of Rps6kb1


Analytical, diagnostic and therapeutic context of Rps6kb1


  1. Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase. Sanada, S., Node, K., Asanuma, H., Ogita, H., Takashima, S., Minamino, T., Asakura, M., Liao, Y., Ogai, A., Kim, J., Hori, M., Kitakaze, M. J. Am. Coll. Cardiol. (2002) [Pubmed]
  2. Regulation of ERK/JNK/p70S6K in two rat models of liver injury and fibrosis. Svegliati-Baroni, G., Ridolfi, F., Caradonna, Z., Alvaro, D., Marzioni, M., Saccomanno, S., Candelaresi, C., Trozzi, L., Macarri, G., Benedetti, A., Folli, F. J. Hepatol. (2003) [Pubmed]
  3. Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes. Ono, Y., Ito, H., Tamamori, M., Nozato, T., Adachi, S., Abe, S., Marumo, F., Hiroe, M. Jpn. Circ. J. (2000) [Pubmed]
  4. Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide. Price, D.J., Gunsalus, J.R., Avruch, J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Kenerson, H.L., Aicher, L.D., True, L.D., Yeung, R.S. Cancer Res. (2002) [Pubmed]
  6. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. Jeon, S., Kim, S., Park, J.B., Suh, P.G., Kim, Y.S., Bae, C.D., Park, J. J. Biol. Chem. (2002) [Pubmed]
  7. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., Evan, G. Nature (1997) [Pubmed]
  8. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Leibiger, I.B., Leibiger, B., Moede, T., Berggren, P.O. Mol. Cell (1998) [Pubmed]
  9. Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor. Svegliati-Baroni, G., Ridolfi, F., Hannivoort, R., Saccomanno, S., Homan, M., De Minicis, S., Jansen, P.L., Candelaresi, C., Benedetti, A., Moshage, H. Gastroenterology (2005) [Pubmed]
  10. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina, L., Gruppuso, P.A., Wands, J.R. Gastroenterology (2003) [Pubmed]
  11. Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway. Bragado, M.J., Groblewski, G.E., Williams, J.A. Gastroenterology (1998) [Pubmed]
  12. Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Haider, U.G., Sorescu, D., Griendling, K.K., Vollmar, A.M., Dirsch, V.M. Mol. Pharmacol. (2002) [Pubmed]
  13. Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats. Sanada, S., Node, K., Minamino, T., Takashima, S., Ogai, A., Asanuma, H., Ogita, H., Liao, Y., Asakura, M., Kim, J., Hori, M., Kitakaze, M. Hypertension (2003) [Pubmed]
  14. Regulation of protein kinase activities in PC12 pheochromocytoma cells. Blenis, J., Erikson, R.L. EMBO J. (1986) [Pubmed]
  15. Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase. Boluyt, M.O., Zheng, J.S., Younes, A., Long, X., O'Neill, L., Silverman, H., Lakatta, E.G., Crow, M.T. Circ. Res. (1997) [Pubmed]
  16. Activation of p70 S6 protein kinase is necessary for angiotensin II-induced hypertrophy in neonatal rat cardiac myocytes. Takano, H., Komuro, I., Zou, Y., Kudoh, S., Yamazaki, T., Yazaki, Y. FEBS Lett. (1996) [Pubmed]
  17. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett, P.E., Blackshaw, S., Lai, M.M., Qureshi, I.A., Burnett, A.F., Sabatini, D.M., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  18. U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways. Fukazawa, H., Uehara, Y. Cancer Res. (2000) [Pubmed]
  19. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. Wu, X., Reiter, C.E., Antonetti, D.A., Kimball, S.R., Jefferson, L.S., Gardner, T.W. J. Biol. Chem. (2004) [Pubmed]
  20. Betaxolol inhibits extracellular signal-regulated kinase and P70S6 kinase activities and gene expressions of platelet-derived growth factor A-chain and transforming growth factor-beta1 in Dahl salt-sensitive hypertensive rats. Kobayashi, N., Nakano, S., Mori, Y., Mita, S., Kobayashi, T., Honda, T., Tsubokou, Y., Matsuoka, H. Hypertens. Res. (2002) [Pubmed]
  21. Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells. Obata, T., Kashiwagi, A., Maegawa, H., Nishio, Y., Ugi, S., Hidaka, H., Kikkawa, R. Circ. Res. (1996) [Pubmed]
  22. Inhibition of phosphatidylinositol 3-kinase and p70S6 kinase blocks osteogenic protein-1 induction of alkaline phosphatase activity in fetal rat calvaria cells. Shoba, L.N., Lee, J.C. J. Cell. Biochem. (2003) [Pubmed]
  23. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. Kenessey, A., Ojamaa, K. J. Biol. Chem. (2006) [Pubmed]
  24. Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. Wang, L., Rolfe, M., Proud, C.G. Biochem. J. (2003) [Pubmed]
  25. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. Anthony, J.C., Yoshizawa, F., Anthony, T.G., Vary, T.C., Jefferson, L.S., Kimball, S.R. J. Nutr. (2000) [Pubmed]
  26. Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. Jiang, Y.P., Ballou, L.M., Lin, R.Z. J. Biol. Chem. (2001) [Pubmed]
  27. Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats. Minamino, T., Kitakaze, M., Papst, P.J., Ueda, Y., Sakata, Y., Asanuma, H., Ogai, A., Kuzuya, T., Terada, N., Hori, M. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (2000) [Pubmed]
  28. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. Chan, A.Y., Soltys, C.L., Young, M.E., Proud, C.G., Dyck, J.R. J. Biol. Chem. (2004) [Pubmed]
  29. Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor. Iwasaki, H., Eguchi, S., Ueno, H., Marumo, F., Hirata, Y. Endocrinology (1999) [Pubmed]
  30. Insulin and ribosomal protein S6 kinase in rat pancreatic acini. Sung, C.K., Williams, J.A. Diabetes (1989) [Pubmed]
  31. Differential subcellular actions of ACE inhibitors and AT(1) receptor antagonists on cardiac remodeling induced by chronic inhibition of NO synthesis in rats. Sanada, S., Kitakaze, M., Node, K., Takashima, S., Ogai, A., Asanuma, H., Sakata, Y., Asakura, M., Ogita, H., Liao, Y., Fukushima, T., Yamada, J., Minamino, T., Kuzuya, T., Hori, M. Hypertension (2001) [Pubmed]
  32. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Harada, H., Andersen, J.S., Mann, M., Terada, N., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells. Nemenoff, R.A., Price, D.J., Mendelsohn, M.J., Carter, E.A., Avruch, J. J. Biol. Chem. (1988) [Pubmed]
  34. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Anthony, J.C., Lang, C.H., Crozier, S.J., Anthony, T.G., MacLean, D.A., Kimball, S.R., Jefferson, L.S. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  35. Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma. Carey, G.B., Liberti, J.P. Arch. Biochem. Biophys. (1995) [Pubmed]
  36. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes. Hers, I., Tavaré, J.M. Biochem. J. (2005) [Pubmed]
  37. Pancreastatin, a chromogranin A-derived peptide, activates protein synthesis signaling cascade in rat adipocytes. González-Yanes, C., Sánchez-Margalet, V. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  38. Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats. Yoshizawa, F., Hirayama, S., Sekizawa, H., Nagasawa, T., Sugahara, K. J. Nutr. Sci. Vitaminol. (2002) [Pubmed]
  39. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. Kozma, S.C., Ferrari, S., Bassand, P., Siegmann, M., Totty, N., Thomas, G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  40. Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver. Wolfe, L., Bradford, A.P., Klarlund, J.K., Czech, M.P. J. Biol. Chem. (1992) [Pubmed]
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