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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Circadian variation in the induction of intestinal tumors by N-methyl-N-nitrosourea in male C57BL/6N mice.

Male C57BL/6N mice were administered a single ip injection of 30 mg of N-methyl-N-nitrosourea (MNU)/kg of body weight. Additional groups were treated similarly every 3 hours for the next 24 hours. Adenocarcinomas of the small intestine were the major treatment-related tumors, with the total incidence being 38% at 250 days after injection. There was a significant circadian variation for tumor induction; the maximum number of intestinal tumors (approximately equal to 55%) tended to occur when the MNU was administered during the middle of the light period (6:00 to 18:00), while the tumor incidence was at a minimum (approximately equal to 10%) when the MNU was given in the middle of the dark phase (18:00 to 6:00). These data are discussed in relation to DNA synthesis and repair and MNU-induced cellular toxicity.[1]

References

  1. Circadian variation in the induction of intestinal tumors by N-methyl-N-nitrosourea in male C57BL/6N mice. Beland, F.A., Dooley, K.L., Sheldon, W.G., Delongchamp, R.R. J. Natl. Cancer Inst. (1988) [Pubmed]
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