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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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2-Nitropropane induces DNA repair synthesis in rat hepatocytes in vitro and in vivo.

The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hepatocytes from males than in those from females. 1-NP was not active in vitro or in vivo. 2-NP and 1-NP did not induce repair in cell lines of extrahepatic origin derived from rat, mouse, hamster and man. The results are consistent with the reported carcinogenicity of 2-NP in rat liver and suggest that the formation of hepatocarcinomas by 2-NP is due to the generation of a genotoxic metabolite from 2-NP by liver-specific metabolism.[1]

References

  1. 2-Nitropropane induces DNA repair synthesis in rat hepatocytes in vitro and in vivo. Andrae, U., Homfeldt, H., Vogl, L., Lichtmannegger, J., Summer, K.H. Carcinogenesis (1988) [Pubmed]
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