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A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (tartrazine) in mice.

Charles River CD-1 mice were fed FD & C Yellow No. 5 in the diet at levels of 0.0, 0.0, 0.5, 1.5 or 5.0% in a long-term toxicity/carcinogenicity study. Each group consisted of 60 males and 60 females. Maximum exposure was 104 wk for both males and females. No consistent, significant compound-related adverse effects were noted. The no-observed-adverse effect level established in this study was 5.0% (8103 mg/kg/day and 9735 mg/kg/day for male and female mice, respectively.)[1]

References

  1. A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (tartrazine) in mice. Borzelleca, J.F., Hallagan, J.B. Food Chem. Toxicol. (1988) [Pubmed]
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