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MeSH Review

No-Observed-Adverse-Effect Level

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Disease relevance of No-Observed-Adverse-Effect Level


High impact information on No-Observed-Adverse-Effect Level

  • It is suggested that the BMD method is used as a first choice and that in cases where it is not possible to fit a model to the data the traditional NOAEL approach should be used instead [6].
  • When available, cholinergic effects or brain AChE inhibition data should take precedence over RBC AChE for determining no-observed-effect levels (NOELs) [7].
  • In rat forestomach, an apparent no observed effect level for ad libitum fed rats was found at 0.5% BHA (LI) and at 0.75% BHA (potential doubling time) [8].
  • Six-week-old CD-1 mice were treated with 0 (solvent as control), 8 mg/kg (a dose previously established in mice as the maternal no-observed-adverse-effect level), and 16 mg/kg doses of sodium arsenite every 2 days for a total of seven i.p. injections ver a period of 14 days [9].
  • The 95th percentile of vitamin A intake from foods and supplements for nonpregnant, nonlactating women aged 19-30 y also exceeds the UL but is below the NOAEL for women of reproductive age [10].

Chemical compound and disease context of No-Observed-Adverse-Effect Level


Biological context of No-Observed-Adverse-Effect Level


Anatomical context of No-Observed-Adverse-Effect Level


Associations of No-Observed-Adverse-Effect Level with chemical compounds


Gene context of No-Observed-Adverse-Effect Level

  • The no-observable-adverse-effect level (NOAEL) of OPG was 15 mg/kg [31].
  • The above data suggests the NOAEL of bFGF in Beagle dogs is >480 mg/kg/d [32].
  • A 1-mo toxicity study followed by a 1-mo recovery period of recombinant human basic fibroblast growth factor (bFGF) was performed using Beagle dogs at doses of 30, 120 or 480 mg/kg/d to estimate the no observed adverse effect level (NOAEL) [32].
  • Based on animal data, regulatory strategy generally has been to postulate a no-observed-effect level (NOEL) for toxic effects and to divide this by a safety factor, usually 100, to establish acceptable levels for humans [33].
  • The no-adverse-effect level (NOAEL) for PKD was determined to be 500 ppm [34].

Analytical, diagnostic and therapeutic context of No-Observed-Adverse-Effect Level


  1. An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme. Voss, K.A., Riley, R.T., Norred, W.P., Bacon, C.W., Meredith, F.I., Howard, P.C., Plattner, R.D., Collins, T.F., Hansen, D.K., Porter, J.K. Environ. Health Perspect. (2001) [Pubmed]
  2. Two-year drinking-water study of formaldehyde in rats. Til, H.P., Woutersen, R.A., Feron, V.J., Hollanders, V.H., Falke, H.E., Clary, J.J. Food Chem. Toxicol. (1989) [Pubmed]
  3. Subchronic inhalation and oral toxicity of N-vinylpyrrolidone-2. Studies in rodents. Klimisch, H.J., Deckardt, K., Gembardt, C., Hildebrand, B., Küttler, K., Roe, F.J. Food Chem. Toxicol. (1997) [Pubmed]
  4. Developmental toxicity of oral n-butylamine hydrochloride and inhaled n-butylamine in rats. Gamer, A.O., Hellwig, J., van Ravenzwaay, B., Heliwig, J. Food Chem. Toxicol. (2002) [Pubmed]
  5. Developmental toxicity of orally administered thiabendazole in ICR mice. Lankas, G.R., Nakatsuka, T., Ban, Y., Komatsu, T., Matsumoto, H. Food Chem. Toxicol. (2001) [Pubmed]
  6. The benchmark dose method--review of available models, and recommendations for application in health risk assessment. Filipsson, A.F., Sand, S., Nilsson, J., Victorin, K. Crit. Rev. Toxicol. (2003) [Pubmed]
  7. Regulating and assessing risks of cholinesterase-inhibiting pesticides: divergent approaches and interpretations. Carlock, L.L., Chen, W.L., Gordon, E.B., Killeen, J.C., Manley, A., Meyer, L.S., Mullin, L.S., Pendino, K.J., Percy, A., Sargent, D.E., Seaman, L.R., Svanborg, N.K., Stanton, R.H., Tellone, C.I., Van Goethem, D.L. Journal of toxicology and environmental health. Part B, Critical reviews. (1999) [Pubmed]
  8. Dose-dependent effects of short-term dietary administration of the food additive butylated hydroxyanisole on cell kinetic parameters in rat gastro-intestinal tract. Verhagen, H., Furnée, C., Schutte, B., Bosman, F.T., Blijham, G.H., Henderson, P.T., ten Hoor, F., Kleinjans, J.C. Carcinogenesis (1990) [Pubmed]
  9. In vivo effects of arsenite on meiosis, preimplantation development, and apoptosis in the mouse. Navarro, P.A., Liu, L., Keefe, D.L. Biol. Reprod. (2004) [Pubmed]
  10. Estimating the potential for vitamin A toxicity in women and young children. Allen, L.H., Haskell, M. J. Nutr. (2002) [Pubmed]
  11. Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms. Charles, J.M., Hanley, T.R., Wilson, R.D., van Ravenzwaay, B., Bus, J.S. Toxicol. Sci. (2001) [Pubmed]
  12. Subchronic inhalation toxicity study of caprolactam (with a 4-week recovery) in the rat via whole-body exposures. Reinhold, R.W., Hoffman, G.M., Bolte, H.F., Rinehart, W.E., Rusch, G.M., Parod, R.J., Kayser, M. Toxicol. Sci. (1998) [Pubmed]
  13. Study on embryo-foetotoxicity of beta-myrcene in the rat. Delgado, I.F., Carvalho, R.R., Nogueira, A.C., Mattos, A.P., Figueiredo, L.H., Oliveira, S.H., Chahoud, I., Paumgartten, F.J. Food Chem. Toxicol. (1993) [Pubmed]
  14. Subchronic oral toxicity of di-n-octyl phthalate and di(2-Ethylhexyl) phthalate in the rat. Poon, R., Lecavalier, P., Mueller, R., Valli, V.E., Procter, B.G., Chu, I. Food Chem. Toxicol. (1997) [Pubmed]
  15. Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats. Til, H.P., Falke, H.E., Prinsen, M.K., Willems, M.I. Food Chem. Toxicol. (1997) [Pubmed]
  16. Strategies for setting occupational exposure limits for particles. Greim, H.A., Ziegler-Skylakakis, K. Environ. Health Perspect. (1997) [Pubmed]
  17. Diethanolamine induces hepatic choline deficiency in mice. Lehman-McKeeman, L.D., Gamsky, E.A., Hicks, S.M., Vassallo, J.D., Mar, M.H., Zeisel, S.H. Toxicol. Sci. (2002) [Pubmed]
  18. Subchronic inhalation toxicity of diglyme. Valentine, R., O'Neill, A.J., Lee, K.P., Kennedy, G.L. Food Chem. Toxicol. (1999) [Pubmed]
  19. Reference dose for perchlorate based on thyroid hormone change in pregnant women as the critical effect. Strawson, J., Zhao, Q., Dourson, M. Regulatory toxicology and pharmacology : RTP. (2004) [Pubmed]
  20. Reproductive and developmental toxicity in F1 Sprague-Dawley male rats exposed to di-n-butyl phthalate in utero and during lactation and determination of its NOAEL. Zhang, Y., Jiang, X., Chen, B. Reprod. Toxicol. (2004) [Pubmed]
  21. Inhalation toxicity of methanol/gasoline in rats: effects of 13-week exposure. Poon, R., Park, G., Viau, C., Chu, I., Potvin, M., Vincent, R., Valli, V. Toxicology and industrial health. (1998) [Pubmed]
  22. Reanalysis with optimized power of red blood cell acetylcholinesterase activity from a 1-year dietary treatment of dogs to chlorpyrifos. Mattsson, J.L., Holden, L., Eisenbrandt, D.L., Gibson, J.E. Toxicology (2001) [Pubmed]
  23. A carcinogenesis reversibility study of the effects of butylated hydroxyanisole on the forestomach and urinary bladder in male Fischer 344 rats. Nera, E.A., Iverson, F., Lok, E., Armstrong, C.L., Karpinski, K., Clayson, D.B. Toxicology (1988) [Pubmed]
  24. Acute, subchronic and chronic safety studies with genistein in rats. Michael McClain, R., Wolz, E., Davidovich, A., Pfannkuch, F., Edwards, J.A., Bausch, J. Food Chem. Toxicol. (2006) [Pubmed]
  25. Thyroid health status of ammonium perchlorate workers: a cross-sectional occupational health study. Lamm, S.H., Braverman, L.E., Li, F.X., Richman, K., Pino, S., Howearth, G. J. Occup. Environ. Med. (1999) [Pubmed]
  26. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Elder, A., Gelein, R., Finkelstein, J.N., Driscoll, K.E., Harkema, J., Oberdörster, G. Toxicol. Sci. (2005) [Pubmed]
  27. Selective vulnerability of dopaminergic systems to industrial chemicals: risk assessment of related neuroendocrine changes. Mutti, A., Smargiassi, A. Toxicology and industrial health. (1998) [Pubmed]
  28. A dose-response study following in utero and lactational exposure to di(2-ethylhexyl)phthalate: effects on female rat reproductive development. Grande, S.W., Andrade, A.J., Talsness, C.E., Grote, K., Chahoud, I. Toxicol. Sci. (2006) [Pubmed]
  29. Derivation of a chemical-specific adjustment factor (CSAF) for use in the assessment of risk from chronic exposure to ethylene glycol: Application of international programme for chemical safety guidelines. Palmer, R.B., Brent, J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  30. Neurotoxicologic examination of rats exposed to 1,1,2,2-tetrachloroethylene (perchloroethylene) vapor for 13 weeks. Mattsson, J.L., Albee, R.R., Yano, B.L., Bradley, G., Spencer, P.J. Neurotoxicology and teratology. (1998) [Pubmed]
  31. A toxicity profile of osteoprotegerin in the cynomolgus monkey. Smith, B.B., Cosenza, M.E., Mancini, A., Dunstan, C., Gregson, R., Martin, S.W., Smith, S.Y., Davis, H. International journal of toxicology. (2003) [Pubmed]
  32. One-month parenteral toxicity study of recombinant human basic fibroblast growth factor in dogs. Kim, M.Y., Shin, M.K., Son, J.W., Kwak, H.I., Fang, M.Z., Bae, M.O., Kim, J.H., Cho, M.H., Kang, K.K., Kim, W.B., Ahn, B.O. Veterinary and human toxicology. (2000) [Pubmed]
  33. Quantitative risk analysis for quantal reproductive and developmental effects. Gaylor, D.W. Environ. Health Perspect. (1989) [Pubmed]
  34. Polycystic kidney disease induced in F(1) Sprague-Dawley rats fed para-nonylphenol in a soy-free, casein-containing diet. Latendresse, J.R., Newbold, R.R., Weis, C.C., Delclos, K.B. Toxicol. Sci. (2001) [Pubmed]
  35. 28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period. Miklós, A., Magyar, Z., Kiss, E., Novák, I., Grósz, M., Nyitray, M., Dereszlay, I., Czégeni, E., Druga, A., Howes, J., Bodor, N. Die Pharmazie. (2002) [Pubmed]
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