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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Light stimulates the rapid formation of inositol trisphosphate in squid retinas.

To test the hypothesis that inositol trisphosphate (InsP3) mediates adaptation and excitation in invertebrate photoreceptors, we measured its formation on a rapid time scale in squid retinas. For squid, excitation and adaption occurs within 0.1 and 1-2 s respectively. We could detect an elevation in InsP3 within 200 ms of a bright flash. This increase is about 240% over dark basal levels and is maintained for at least 2 min after a flash. The increase probably occurs in the photoreceptors, which are the only neurons in squid retinas. Analysis by h.p.l.c. indicates that the light-regulated isomer is Ins(1,4,5)P3, which is formed by the hydrolysis of phosphatidylinositol bisphosphate (PtdInsP2).[1]


  1. Light stimulates the rapid formation of inositol trisphosphate in squid retinas. Szuts, E.Z., Wood, S.F., Reid, M.S., Fein, A. Biochem. J. (1986) [Pubmed]
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