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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Troleandomycin-triazolam interaction in healthy volunteers: pharmacokinetic and psychometric evaluation.

Seven healthy volunteers received a single oral dose of triazolam 0.25 mg after 7 days on troleandomycin 2 g/day p.o. or placebo in a double-blind cross-over study. Plasma triazolam and psychometric and memory tests (including Critical Flicker Fusion threshold, Choice Reaction Time, Digit Symbol Substitution and Self-Rating Scales) were assessed at regular intervals after the final treatment. Troleandomycin was found to prolong the psychomotor impairment and amnesia produced by triazolam. There was a significant enhancement of the AUC, the peak concentration and the delay to tmax of triazolam after 7 days treatment with troleandomycin compared to placebo. Thus, there is a pharmacokinetic interaction, and the combination of triazolam and troleandomycin should be avoided or the dose of triazolam should be adjusted. The most likely mechanism is a diminished hepatic first-pass effect, and a decrease in the apparent oral clearance of triazolam.[1]

References

  1. Troleandomycin-triazolam interaction in healthy volunteers: pharmacokinetic and psychometric evaluation. Warot, D., Bergougnan, L., Lamiable, D., Berlin, I., Bensimon, G., Danjou, P., Puech, A.J. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
 
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